CD33 Antibody (P67.6): sc-19660

CD33 Antibody (P67.6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD33 protein of human origin by immunofluorescence (IF) and flow cytometry (FCM). Anti-CD33 antibody (P67.6) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. CD33 is a type I transmembrane glycoprotein predominantly expressed on granulocyte and macrophage precursors in the bone marrow, while CD33 is notably absent from pluripotent stem cells, making CD33 a critical marker for identifying myelogenous leukemia cells as opposed to lymphoid or erythroid leukemias. CD33 plays a significant role as a sialic acid-dependent cell adhesion molecule, which is essential for mediating interactions between cells in the immune system. This function is particularly important as CD33 influences the migration and adhesion of immune cells, thereby impacting immune responses and inflammation. Understanding the role of CD33 in cell adhesion can provide insights into CD33′s potential as a therapeutic target in various hematological malignancies.

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CD33 Antibody (P67.6) References:

1. Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells.  |  Vitale, C., et al. 2001. Proc Natl Acad Sci U S A. 98: 5764-9. PMID: 11320212
2. Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties.  |  Andrews, RG., et al. 1989. J Exp Med. 169: 1721-31. PMID: 2469766
3. Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.  |  Kim, MY., et al. 2018. Cell. 173: 1439-1453.e19. PMID: 29856956
4. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.  |  Griciuc, A., et al. 2019. Neuron. 103: 820-835.e7. PMID: 31301936
5. Characterization of monoclonal antibodies to the human myeloid-differentiation antigen, 'gp67' (CD-33).  |  Favaloro, EJ., et al. 1987. Dis Markers. 5: 215-25. PMID: 3502990
6. Primary CD33-targeting CAR-NK cells for the treatment of acute myeloid leukemia.  |  Albinger, N., et al. 2022. Blood Cancer J. 12: 61. PMID: 35418180
7. A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells.  |  Griffin, JD., et al. 1984. Leuk Res. 8: 521-34. PMID: 6590930
8. Expression of an early myelopoietic antigen (CD33) on a subset of human umbilical cord blood-derived natural killer cells.  |  Handgretinger, R., et al. 1993. Immunol Lett. 37: 223-8. PMID: 7505004
9. Further investigations on the expression of HLA-DR, CD33 and CD13 surface antigens in purified bone marrow and peripheral blood CD34+ haematopoietic progenitor cells.  |  Pierelli, L., et al. 1993. Br J Haematol. 84: 24-30. PMID: 7687858
10. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules.  |  Freeman, SD., et al. 1995. Blood. 85: 2005-12. PMID: 7718872
11. A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33.  |  Sgroi, D., et al. 1996. J Biol Chem. 271: 18803-9. PMID: 8702538
12. The Sialoadhesins--a family of sialic acid-dependent cellular recognition molecules within the immunoglobulin superfamily.  |  Kelm, S., et al. 1996. Glycoconj J. 13: 913-26. PMID: 8981082

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD33 Antibody (P67.6) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-CD33 Antibody (P67.6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD33 Antibody (P67.6) Specifications

Alternate Product Name: CD33

Product Clone Name: P67.6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CD33

Epitope Species: human

Product Reactivity/Detection: CD33

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for CD33 Antibody (P67.6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin