CD3-γ/δ Antibody (HMT3-2): sc-101415
- CD3-γ/δ Antibody (HMT3-2) is a Armenian hamster monoclonal IgG2b provided at 200 µg/ml
- raised against CD3 of human origin
- recommended for detection of CD3γ and CD3δ of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD3-γ/δ Antibody (HMT3-2). This work is in progress.
CD3-γ/δ Antibody (HMT3-2) is a hamster monoclonal IgG2b antibody that detects CD3-γ/δ in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. CD3-γ/δ plays a crucial role in T cell activation by forming part of the T cell receptor (TCR) complex, which is essential for recognizing foreign antigens and initiating intracellular signaling pathways that lead to T cell activation. The CD3 complex is composed of several invariant polypeptide chains, including the gamma and delta chains, which are vital for the transduction of activation signals. These chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) that are phosphorylated upon TCR engagement, serving as docking sites for key signaling molecules such as ZAP-70 and Syk. The interaction of these kinases with the phosphorylated ITAMs is critical for the downstream signaling cascade that ultimately results in T cell proliferation and differentiation. Understanding the structure and function of CD3-γ/δ is important for elucidating the mechanisms of T cell responses and developing targeted immunotherapies. Anti-CD3-γ/δ antibody (HMT3-2) is an invaluable tool for researchers studying T cell biology and immune responses.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD3-γ/δ Antibody (HMT3-2) | sc-101415 | 200 µg/ml | $316.00 |