CD3-γ/δ Antibody (H25-1157): sc-101413
- CD3-γ/δ Antibody (H25-1157) is a Armenian hamster monoclonal IgG2b provided at 200 µg/ml
- raised against CD3 of human origin
- recommended for detection of CD3γ and CD3δ of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD3-γ/δ Antibody (H25-1157). This work is in progress.
CD3-γ/δ Antibody (H25-1157) is a hamster monoclonal IgG2b antibody that detects CD3-γ/δ in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. CD3-γ/δ plays a crucial role in the immune response by forming part of the T cell receptor (TCR) complex, which is essential for T cell activation and signaling. The TCR complex, which includes CD3-γ and CD3-δ, is responsible for recognizing foreign antigens and initiating a cascade of intracellular signals that lead to T cell activation. This process is vital for the adaptive immune response, as it enables T cells to respond effectively to pathogens. The CD3 complex is composed of multiple invariant polypeptide chains, including the γ and δ chains, which each contain immunoreceptor tyrosine-based activation motifs (ITAMs) that are critical for signal transduction. The phosphorylation of these ITAMs creates docking sites for protein kinases, such as ZAP-70, which further propagate the activation signal within the cell. Understanding the structure and function of CD3-γ/δ is important for developing therapeutic strategies aimed at modulating T cell responses in various diseases, including cancer and autoimmune disorders. Anti-CD3-γ/δ antibody (H25-1157) is an invaluable tool for researchers studying T cell biology and the mechanisms of immune activation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD3-γ/δ Antibody (H25-1157) | sc-101413 | 200 µg/ml | $322.00 |