CD27 Antibody (M-T271): sc-19653
- CD27 Antibody (M-T271) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against CD27 of human origin
- recommended for detection of CD27 of human origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD27 Antibody (M-T271). These reagents are now offered in bundles with CD27 Antibody (M-T271) (see ordering information below).
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CD27 Antibody (M-T271) is a mouse monoclonal IgG1 antibody that detects CD27 in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. CD27 is a crucial member of the tumor necrosis factor receptor family, functioning as a homodimeric lymphocyte-specific surface antigen predominantly found on T and B lymphocytes. CD27 expression is significantly upregulated upon T cell receptor activation, which is essential for generating co-stimulatory signals alongside CD27L, thereby facilitating complete T cell activation. CD27-CD27L interaction is vital for the immune response, as CD27 enhances T cell proliferation and survival, ultimately contributing to effective adaptive immunity. Additionally, CD27 plays a role in regulating the balance between immune activation and tolerance, making CD27 a key player in various immunological processes. Anti-CD27 antibody (M-T271) is an invaluable tool for researchers studying T cell dynamics and the mechanisms underlying immune responses, particularly in the context of cancer and autoimmune diseases.
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CD27 Antibody (M-T271) References:
- The CD27-CD70 pathway and pathogenesis of autoimmune disease. | Han, BK., et al. 2016. Semin Arthritis Rheum. 45: 496-501. PMID: 26359318
- The role of CD27 in anti-viral T-cell immunity. | Grant, EJ., et al. 2017. Curr Opin Virol. 22: 77-88. PMID: 28086150
- The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. | Buchan, SL., et al. 2018. Blood. 131: 39-48. PMID: 29118006
- CD27 on human memory B cells-more than just a surface marker. | Grimsholm, O. 2023. Clin Exp Immunol. 213: 164-172. PMID: 36508329
- Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction. | Gong, L., et al. 2023. Nat Commun. 14: 1912. PMID: 37024479
- Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function. | Ma, X., et al. 2023. JCI Insight. 8: PMID: 37874660
- Identification and Characterization of CD8+ CD27+ CXCR3- T Cell Dysregulation and Progression-Associated Biomarkers in Systemic Lupus Erythematosus. | Zhang, L., et al. 2023. Adv Sci (Weinh). 10: e2300123. PMID: 37875396
- B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis. | Ulutekin, C., et al. 2024. Cell Rep Med. 5: 101351. PMID: 38134930
- Prognostic marker CD27 and its micro-environmental in multiple myeloma. | Wang, X., et al. 2024. BMC Cancer. 24: 352. PMID: 38504180
- IgA class-switched CD27-CD21+ B cells in IgA nephropathy. | Popova, A., et al. 2024. Nephrol Dial Transplant.. PMID: 39020236
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD27 Antibody (M-T271) | sc-19653 | 200 µg/ml | $322.00 | |||
CD27 Antibody (M-T271): m-IgG Fc BP-HRP Bundle | sc-536627 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD27 Antibody (M-T271): m-IgGκ BP-HRP Bundle | sc-533784 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD27 Antibody (M-T271): m-IgG1 BP-HRP Bundle | sc-544716 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD27 Antibody (M-T271) FITC | sc-19653 FITC | 200 µg/ml | $336.00 | |||
CD27 Antibody (M-T271) PE | sc-19653 PE | 200 µg/ml | $349.00 |