CD26 Antibody (202.36): sc-7633
- CD26 Antibody (202.36) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- raised against a human T cell clone
- CD26 Antibody (202.36) is recommended for detection of CD26 of human origin by IP and FCM
- Anti-CD26 Antibody (202.36) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD26 Antibody (202.36). These reagents are now offered in bundles with CD26 Antibody (202.36) (see ordering information below).
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CD26 Antibody (202.36) is a mouse monoclonal IgG2b kappa light chain antibody that detects CD26 of human origin by immunoprecipitation (IP) and flow cytometry (FCM). Anti-CD26 antibody (202.36) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD26, also known as dipeptidyl peptidase 4 (DPPIV), plays a crucial role in immune regulation, functioning as a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. This enzymatic activity is vital for modulating the activity of various bioactive peptides, including chemokines, which are essential for immune cell trafficking and activation. CD26 is predominantly located on the surface of T cells and other immune cells, where CD26 participates in the formation of the immunological synapse, enhancing T cell activation and cytokine production. CD26′s interaction with other proteins, such as CXCR4 and adenosine deaminase, underscores CD26′s importance in the immune response and potential implications in the pathophysiology of diseases, including HIV infection and various cancers. CD26′s ability to influence T helper 1 cytokine production, such as interferon-gamma, tumor necrosis factor-alpha, and interleukin-6, highlights CD26′s significance in both normal immune function and disease processes, making CD26 (202.36) monoclonal antibody a valuable tool for researchers studying immune regulation and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD26 Antibody (202.36) References:
- CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology. | Mortier, A., et al. 2016. J Leukoc Biol. 99: 955-69. PMID: 26744452
- A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target. | Ohnuma, K., et al. 2018. Front Biosci (Landmark Ed). 23: 1754-1779. PMID: 29772527
- CD26/DPP4 - a potential biomarker and target for cancer therapy. | Enz, N., et al. 2019. Pharmacol Ther. 198: 135-159. PMID: 30822465
- The Role of Post-Translational Modifications of Chemokines by CD26 in Cancer. | De Zutter, A., et al. 2021. Cancers (Basel). 13: PMID: 34503058
- Distinctive CD26 Expression on CD4 T-Cell Subsets. | Cordero, OJ., et al. 2021. Biomolecules. 11: PMID: 34680079
- The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells. | Chitadze, G., et al. 2021. Cancers (Basel). 13: PMID: 34885056
- CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma. | Nishina, S. and Hino, K. 2022. Cancers (Basel). 14: PMID: 35053615
- CD26 Induces Colorectal Cancer Angiogenesis and Metastasis through CAV1/MMP1 Signaling. | Ng, L., et al. 2022. Int J Mol Sci. 23: PMID: 35163100
- cd26 Knockdown Negatively Affects Porcine Parthenogenetic Preimplantation Embryo Development. | Hwang, IS., et al. 2022. Animals (Basel). 12: PMID: 35804561
- Functional roles of CD26/DPP4 in bleomycin-induced pulmonary fibrosis. | Koyanagi, Y., et al. 2023. Physiol Rep. 11: e15645. PMID: 36949656
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD26 Antibody (202.36) | sc-7633 | 200 µg/ml | $322.00 | |||
CD26 Antibody (202.36): m-IgGκ BP-HRP Bundle | sc-520506 | 200 µg Ab, 40 µg BP | $361.00 | |||
CD26 Antibody (202.36): m-IgG2b BP-HRP Bundle | sc-548834 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD26 Antibody (202.36) AC | sc-7633 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD26 Antibody (202.36) HRP | sc-7633 HRP | 200 µg/ml | $322.00 | |||
CD26 Antibody (202.36) FITC | sc-7633 FITC | 200 µg/ml | $336.00 | |||
CD26 Antibody (202.36) PE | sc-7633 PE | 200 µg/ml | $349.00 | |||
CD26 Antibody (202.36) Alexa Fluor® 488 | sc-7633 AF488 | 200 µg/ml | $364.00 | |||
CD26 Antibody (202.36) Alexa Fluor® 546 | sc-7633 AF546 | 200 µg/ml | $364.00 | |||
CD26 Antibody (202.36) Alexa Fluor® 594 | sc-7633 AF594 | 200 µg/ml | $364.00 | |||
CD26 Antibody (202.36) Alexa Fluor® 647 | sc-7633 AF647 | 200 µg/ml | $364.00 | |||
CD26 Antibody (202.36) Alexa Fluor® 680 | sc-7633 AF680 | 200 µg/ml | $364.00 | |||
CD26 Antibody (202.36) Alexa Fluor® 790 | sc-7633 AF790 | 200 µg/ml | $364.00 |