CD24 Antibody (2Q1282): sc-70598

CD24 Antibody (2Q1282) is a mouse monoclonal IgG1 antibody that detects CD24 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD24 is a glycosylphosphatidylinositol (GPI)-anchored membrane sialoglycoprotein predominantly expressed on pro-B, pre-B, and mature B cells, with expression diminishing following B cell activation. CD24 is also present on granulocytes and a small subset of thymocytes and neuroblastomas, but absent in plasma cells. CD24 plays a crucial role in regulating B cell proliferation and differentiation, serving as an important marker in hematological malignancies and various solid tumors. CD24 localization can shift from an apical position to a cytoplasmic distribution, serving as a surrogate marker for stromal invasion in ovarian serous tumors of borderline malignancy. As a differentiation marker for B cells, CD24 is expressed on mature resting B cells and disappears upon stimulation, highlighting CD24′s importance in understanding B cell biology and cancer research. Anti-CD24 antibody (2Q1282) serves as an essential tool for researchers investigating B cell development and tumor biology.

The preferred CD24 antibody is CD24 Antibody (SN3): sc-19585.