CD23 Antibody (M-L233): sc-23923

CD23 Antibody (M-L233) is a mouse monoclonal IgG1 antibody that detects CD23 in human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD23, also known as the human leukocyte differentiation antigen, is a type II integral membrane glycoprotein predominantly expressed on mature B cells, monocytes, eosinophils, platelets, and dendritic cells, playing a crucial role in the immune response. CD23 functions as a low-affinity IgE receptor, facilitating IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils, which is vital for the body′s defense against parasitic infections and allergic reactions. CD23 exists as an oligomer, requiring cooperative binding of at least two lectin domains for high-affinity IgE binding, and is implicated in antigen presentation by B cells through CD40 interaction. Additionally, CD23 can be cleaved by metalloproteinases such as ADAM8 and ADAM15, leading to the release of a truncated form that acts as a potent mitogenic growth factor, further highlighting CD23′s significance in immune regulation. The presence of two splice variants, CD23a and CD23b, in intestinal cells, which exhibit different localizations in polarized cells, underscores the complexity of CD23′s function and potential implications in various physiological and pathological processes.

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CD23 Antibody (M-L233) References:

1. Distribution of adhesion molecules, IgE, and CD23 in a case of angiolymphoid hyperplasia with eosinophilia.  |  von den Driesch, P., et al. 1992. J Am Acad Dermatol. 26: 799-804. PMID: 1535350
2. The structure of human CD23 and its interactions with IgE and CD21.  |  Hibbert, RG., et al. 2005. J Exp Med. 202: 751-60. PMID: 16172256
3. Soluble CD23 controls IgE synthesis and homeostasis in human B cells.  |  Cooper, AM., et al. 2012. J Immunol. 188: 3199-207. PMID: 22393152
4. Association of T-regulatory cells and CD23/CD21 expression with vitamin D in children with asthma.  |  Chary, AV., et al. 2016. Ann Allergy Asthma Immunol. 116: 447-454.e2. PMID: 27026514
5. Identification of new phosphorylation sites of CD23 in B-cells of patients with chronic lymphocytic leukemia.  |  Maďarová, M., et al. 2018. Leuk Res. 70: 25-33. PMID: 29763855
6. CD23 expression in mantle cell lymphoma is associated with CD200 expression, leukemic non-nodal form, and a better prognosis.  |  Saksena, A., et al. 2019. Hum Pathol. 89: 71-80. PMID: 31054894
7. Human Mesenchymal Stem Cell-Treated Regulatory CD23+CD43+ B Cells Alleviate Intestinal Inflammation.  |  Chen, X., et al. 2019. Theranostics. 9: 4633-4647. PMID: 31367246
8. CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis.  |  Yao, Y., et al. 2020. Allergy. 75: 2599-2612. PMID: 32198890
9. Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction.  |  Pignarre, A., et al. 2021. Blood. 137: 1166-1180. PMID: 33150420
10. Consequences of IgE/CD23-mediated antigen presentation in allergy.  |  Mudde, GC., et al. 1995. Immunol Today. 16: 380-3. PMID: 7546193

The preferred CD23 antibody is CD23 Antibody (BU38): sc-58995.