CD2 Antibody (X53): sc-20046
- CD2 Antibody (X53) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against T-cell lymphoma cells
- recommended for detection of CD2 of human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD2 Antibody (X53) for WB applications. These reagents are now offered in bundles with CD2 Antibody (X53) (see ordering information below).
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CD2 Antibody (X53) is a mouse monoclonal IgG1 antibody that detects CD2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2 mediates cell adhesion through interaction with CD58 ligand, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores its potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (X53) provides a reliable tool for researchers studying T cell activation and immune cell interactions, contributing to a deeper understanding of immune system dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD2 Antibody (X53) References:
- Clues to CD2-associated protein involvement in cytokinesis. | Monzo, P., et al. 2005. Mol Biol Cell. 16: 2891-902. PMID: 15800069
- Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome. | Muhammad, A., et al. 2009. J Immunol. 182: 7672-80. PMID: 19494291
- CD2 regulates responsiveness of activated T cells to interleukin 12. | Gollob, JA., et al. 1995. J Exp Med. 182: 721-31. PMID: 7544396
- CD4, CD8 and CD2 in T cell adhesion and signaling. | Collins, TL., et al. 1993. Curr Top Microbiol Immunol. 184: 223-33. PMID: 7906216
- Alterations of CD2 association with T cell receptor signaling molecules in 'CD2 unresponsive' human T lymphocytes. | Schraven, B., et al. 1993. Eur J Immunol. 23: 119-23. PMID: 8093441
- Soluble CD2 levels in serum during acute Kawasaki disease and infectious mononucleosis. | Furukawa, S., et al. 1993. J Infect Dis. 167: 778-9. PMID: 8095062
- An anti-CD2 monoclonal antibody that both inhibits and stimulates T cell activation recognizes a subregion of CD2 distinct from known ligand-binding sites. | Kozarsky, KF., et al. 1993. Cell Immunol. 150: 235-46. PMID: 8103706
- Production and characterization of soluble and transmembrane murine CD2. Demonstration that CD48 is a ligand for CD2 and that CD48 adhesion is regulated by CD2. | Kaplan, AJ., et al. 1993. J Immunol. 151: 4022-32. PMID: 8104993
- Prolonged allograft survival by the inhibition of costimulatory CD2 signals but not by modulation of CD48 (CD2 ligand) in the rat. | Sido, B., et al. 1996. Transpl Int. 9 Suppl 1: S323-7. PMID: 8959856
- A p56lck-independent pathway of CD2 signaling involves Jun kinase. | Sunder-Plassmann, R. and Reinherz, EL. 1998. J Biol Chem. 273: 24249-57. PMID: 9727049
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (X53) | sc-20046 | 200 µg/ml | $322.00 | |||
CD2 Antibody (X53): m-IgG Fc BP-HRP Bundle | sc-536644 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (X53): m-IgGκ BP-HRP Bundle | sc-533802 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD2 Antibody (X53) FITC | sc-20046 FITC | 200 µg/ml | $336.00 | |||
CD2 Antibody (X53) PE | sc-20046 PE | 200 µg/ml | $349.00 |