CD2 Antibody (MT910): sc-19638
- CD2 Antibody (MT910) is a mouse monoclonal IgG1 κ CD2 antibody, cited in 1 publications, provided at 200 µg/ml
- CD2 Antibody (MT910) is recommended for detection of CD2 of human origin by WB, IP, IF, IHC(P) and ELISA
- CD2 Antibody (MT910) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD2 Antibody (MT910) for WB and IHC(P) applications. These reagents are now offered in bundles with CD2 Antibody (MT910) (see ordering information below).
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CD2 Antibody (MT910) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CD2 (MT910) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD2 protein, also known as the E-rosette receptor, plays a crucial role in immune response by mediating cell adhesion through interaction with CD58 protein, which is essential for T cell activation. CD2 is a transmembrane glycoprotein predominantly expressed on peripheral blood T lymphocytes, natural killer cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2 binding to CD58 ligand enhances activation of antigen-specific T cells, thereby optimizing immune system recognition and facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. This interaction is vital for effective immune responses, making CD2 a significant target for research in immunology and potential therapeutic applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD2 Antibody (MT910) References:
- Congenital nephrotic syndrome in mice lacking CD2-associated protein. | Shih, NY., et al. 1999. Science. 286: 312-5. PMID: 10514378
- The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte. | Fan, Q., et al. 2006. Kidney Int. 69: 1207-15. PMID: 16501493
- Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP. | Guan, F., et al. 2006. Am J Physiol Renal Physiol. 291: F422-8. PMID: 16597608
- Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. | Xia, W., et al. 2006. J Biol Chem. 281: 16799-813. PMID: 16617054
- CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP. | Konishi, H., et al. 2006. J Biol Chem. 281: 28919-31. PMID: 16895919
- CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes. | Tossidou, I., et al. 2007. J Biol Chem. 282: 7457-64. PMID: 17213204
- Mechanism of Cd2+ coordination during slow inactivation in potassium channels. | Raghuraman, H., et al. 2012. Structure. 20: 1332-42. PMID: 22771214
- CD2-mediated adhesion facilitates T lymphocyte antigen recognition function. | Moingeon, P., et al. 1989. Nature. 339: 312-4. PMID: 2566919
- CD2 is involved in regulating cyclic AMP levels in T cells. | Carrera, AC., et al. 1988. Eur J Immunol. 18: 961-4. PMID: 2898370
- Making the T cell receptor go the distance: a topological view of T cell activation. | Shaw, AS. and Dustin, ML. 1997. Immunity. 6: 361-9. PMID: 9133415
- A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. | Dustin, ML., et al. 1998. Cell. 94: 667-77. PMID: 9741631
- Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. | Nishizawa, K., et al. 1998. Proc Natl Acad Sci U S A. 95: 14897-902. PMID: 9843987
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (MT910) | sc-19638 | 200 µg/ml | $322.00 | |||
CD2 Antibody (MT910): m-IgG Fc BP-HRP Bundle | sc-528341 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (MT910): m-IgGκ BP-HRP Bundle | sc-520695 | 200 µg Ab, 40 µg BP | $361.00 | |||
CD2 Antibody (MT910): m-IgG1 BP-HRP Bundle | sc-542878 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD2 Antibody (MT910) AC | sc-19638 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD2 Antibody (MT910) HRP | sc-19638 HRP | 200 µg/ml | $322.00 | |||
CD2 Antibody (MT910) FITC | sc-19638 FITC | 200 µg/ml | $336.00 | |||
CD2 Antibody (MT910) PE | sc-19638 PE | 200 µg/ml | $349.00 | |||
CD2 Antibody (MT910) Alexa Fluor® 488 | sc-19638 AF488 | 200 µg/ml | $364.00 | |||
CD2 Antibody (MT910) Alexa Fluor® 546 | sc-19638 AF546 | 200 µg/ml | $364.00 | |||
CD2 Antibody (MT910) Alexa Fluor® 594 | sc-19638 AF594 | 200 µg/ml | $364.00 | |||
CD2 Antibody (MT910) Alexa Fluor® 647 | sc-19638 AF647 | 200 µg/ml | $364.00 | |||
CD2 Antibody (MT910) Alexa Fluor® 680 | sc-19638 AF680 | 200 µg/ml | $364.00 | |||
CD2 Antibody (MT910) Alexa Fluor® 790 | sc-19638 AF790 | 200 µg/ml | $364.00 |