CD2 Antibody (B-8): sc-136974

CD2 Antibody (B-8) is a mouse monoclonal IgG2a antibody that detects CD2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2 plays a vital role in immune response by mediating cell adhesion through interaction with CD58, also known as the CD2 ligand. The binding of CD2 to CD58 enhances antigen-specific T cell activation, which is essential for effective immune system functioning. Notably, CD2 is involved in optimizing immune recognition by facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune interactions underscores its potential as a therapeutic target and a biomarker for various immune-related conditions. Anti-CD2 antibody (B-8) is an invaluable tool for researchers aiming to explore the complexities of immune cell signaling and interactions.

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CD2 Antibody (B-8) References:

1. Circulating CD2+ monocytes are dendritic cells.  |  Crawford, K., et al. 1999. J Immunol. 163: 5920-8. PMID: 10570278
2. Molecular dissection of the CD2-CD58 counter-receptor interface identifies CD2 Tyr86 and CD58 Lys34 residues as the functional 'hot spot'.  |  Kim, M., et al. 2001. J Mol Biol. 312: 711-20. PMID: 11575926
3. Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2.  |  Chan, PY., et al. 1991. J Cell Biol. 115: 245-55. PMID: 1717480
4. Antibody 12-15 cross-reacts with mouse Fc gamma receptors and CD2: study of thymus expression, genetic polymorphism and biosynthesis of the CD2 protein.  |  Altevogt, P., et al. 1989. Eur J Immunol. 19: 341-6. PMID: 2564824
5. T-cell differentiation antigen cluster 2 (CD2) is a receptor for accessory cells and can generate and/or transduce accessory signals.  |  Suthanthiran, M. 1988. Cell Immunol. 112: 112-22. PMID: 3257905
6. Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors.  |  Wee, S., et al. 1993. J Exp Med. 177: 219-23. PMID: 7678115
7. Identification of a signaling complex involving CD2, zeta chain and p59fyn in T lymphocytes.  |  Gassmann, M., et al. 1994. Eur J Immunol. 24: 139-44. PMID: 7912674
8. Soluble CD2 levels in serum during acute Kawasaki disease and infectious mononucleosis.  |  Furukawa, S., et al. 1993. J Infect Dis. 167: 778-9. PMID: 8095062
9. The receptor function of CD2 in human CD2 transgenic mice is based on highly conserved associations with signal transduction molecules.  |  Wild, MK., et al. 1997. Cell Immunol. 180: 168-75. PMID: 9341747
10. A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.  |  Li, J., et al. 1998. EMBO J. 17: 7320-36. PMID: 9857189

The preferred CD2 antibody is CD2 Antibody (MT910): sc-19638.