CD2 Antibody (3B6): sc-18907
- CD2 Antibody (3B6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against of CD2 of human origin
- recommended for detection of CD2 of mouse, rat and human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD2 Antibody (3B6) for WB applications. These reagents are now offered in bundles with CD2 Antibody (3B6) (see ordering information below).
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CD2 Antibody (3B6) is a mouse monoclonal IgG1 antibody that detects CD2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2′s primary function is to mediate cell adhesion through interaction with CD58 ligand, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, as CD2 facilitates communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores CD2′s potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (3B6) provides a reliable tool for researchers studying T cell activation and immune interactions, contributing to a deeper understanding of immune system dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD2 Antibody (3B6) References:
- Glycosylation Modulates Human CD2-CD58 Adhesion via Conformational Adjustment. | Wang, X., et al. 2015. J Phys Chem B. 119: 6493-501. PMID: 25984915
- Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient mice. | Shiokawa, M., et al. 2017. Int Immunol. 29: 479-485. PMID: 29106539
- CD2 is a surface marker for mouse and rat spermatogonial stem cells. | Kanatsu-Shinohara, M., et al. 2020. J Reprod Dev. 66: 341-349. PMID: 32213736
- Structure-based identification of inhibitors disrupting the CD2-CD58 interactions. | Tripathi, N., et al. 2021. J Comput Aided Mol Des. 35: 337-353. PMID: 33532888
- Crystal structures and identification of novel Cd2+-specific DNA aptamer. | Liu, H., et al. 2023. Nucleic Acids Res. 51: 4625-4636. PMID: 37013991
- Evolution of Cd2+ and Cu+ binding in Helix pomatia metallothioneins. | Valsecchi, R., et al. 2023. Metallomics. 15: PMID: 37738453
- Transcriptional reprogramming via signaling domains of CD2, CD28, and 4-1BB. | De Sousa Linhares, A., et al. 2024. iScience. 27: 109267. PMID: 38455974
- The biology of CD2: adhesion, transmembrane signal, and regulatory receptor of immunity. | Bromberg, JS. 1993. J Surg Res. 54: 258-67. PMID: 8097269
- Modulation of the CD2 receptor and not disruption of the CD2/CD48 interaction is the principal action of CD2-mediated immunosuppression in the rat. | Sido, B., et al. 1997. Cell Immunol. 182: 57-67. PMID: 9427810
- CD2 and the nature of protein interactions mediating cell-cell recognition. | Davis, SJ., et al. 1998. Immunol Rev. 163: 217-36. PMID: 9700513
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (3B6) | sc-18907 | 200 µg/ml | $322.00 | |||
CD2 Antibody (3B6): m-IgG Fc BP-HRP Bundle | sc-536614 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (3B6): m-IgGκ BP-HRP Bundle | sc-533770 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD2 Antibody (3B6): m-IgG1 BP-HRP Bundle | sc-544709 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD2 Antibody (3B6) FITC | sc-18907 FITC | 200 µg/ml | $336.00 | |||
CD2 Antibody (3B6) PE | sc-18907 PE | 200 µg/ml | $349.00 |