CD2 Antibody (1E7E8): sc-53823
- CD2 Antibody (1E7E8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against thymocytes/Sezary T cells of human origin
- recommended for detection of CD2 of human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD2 Antibody (1E7E8) for WB applications. These reagents are now offered in bundles with CD2 Antibody (1E7E8) (see ordering information below).
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CD2 Antibody (1E7E8) is a mouse monoclonal IgG2a antibody that detects CD2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD2 is a crucial transmembrane glycoprotein primarily expressed on peripheral blood T lymphocytes, natural killer (NK) cells, and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD2 mediates cell adhesion by interacting with CD58, which enhances antigen-specific T cell activation. This interaction is vital for optimizing immune system recognition, facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells. The importance of CD2 in immune responses underscores CD2′s potential as a therapeutic target in various immunological disorders. Anti-CD2 antibody (1E7E8) provides a reliable tool for researchers studying T cell activation and immune interactions, contributing to a deeper understanding of immune system dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD2 Antibody (1E7E8) References:
- A subtle role for CD2 in T cell antigen recognition. | van der Merwe, PA. 1999. J Exp Med. 190: 1371-4. PMID: 10562312
- N-glycosylation is required for human CD2 immunoadhesion functions. | Recny, MA., et al. 1992. J Biol Chem. 267: 22428-34. PMID: 1385399
- Effects of imipenem and cefmetazol on lymphocyte receptors CD2, Fc and C3b of complement. | Barriga Ibars, C., et al. 1991. Comp Immunol Microbiol Infect Dis. 14: 297-302. PMID: 1684143
- CD2-positive follicular lymphoma complicated by venous thrombus of surface vein. | Tabata, R., et al. 2014. Ann Hematol. 93: 517-9. PMID: 23783423
- Structural and binding analysis of a two domain extracellular CD2 molecule. | Sayre, PH., et al. 1989. J Exp Med. 169: 995-1009. PMID: 2466941
- Expression of CD2 and CD25 on mast cell populations can be seen outside the setting of systemic mastocytosis. | Cherian, S., et al. 2016. Cytometry B Clin Cytom. 90: 387-92. PMID: 26525770
- Induction and regulation of CD2 mRNA in human lymphocytes. | Malter, JS., et al. 1988. J Immunol. 140: 3233-6. PMID: 2896216
- CD2 is involved in regulating cyclic AMP levels in T cells. | Carrera, AC., et al. 1988. Eur J Immunol. 18: 961-4. PMID: 2898370
- CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. | Boussiotis, VA., et al. 1994. J Exp Med. 180: 1665-73. PMID: 7525835
- Down-modulation of CD2 delays deletion of superantigen-responsive T cells. | Fortner, KA., et al. 1998. Eur J Immunol. 28: 70-9. PMID: 9485187
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD2 Antibody (1E7E8) | sc-53823 | 200 µg/ml | $322.00 | |||
CD2 Antibody (1E7E8): m-IgG Fc BP-HRP Bundle | sc-537003 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (1E7E8): m-IgGκ BP-HRP Bundle | sc-534183 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD2 Antibody (1E7E8): m-IgG2a BP-HRP Bundle | sc-547914 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD2 Antibody (1E7E8) FITC | sc-53823 FITC | 200 µg/ml | $336.00 | |||
CD2 Antibody (1E7E8) PE | sc-53823 PE | 200 µg/ml | $349.00 |