CD1B Antibody (O249): sc-19997

CD1B Antibody (O249) is a mouse monoclonal IgG1 kappa light chain antibody that detects the CD1B protein of human origin by immunofluorescence (IF) and flow cytometry (FCM). Anti-CD1B antibody (O249) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. CD1B is a member of the CD1 multigene family, which encodes five distinct forms of the CD1 T-cell surface glycoprotein in humans, namely CD1A, CD1B, CD1C, CD1D, and CD1E. CD1B plays a crucial role in the immune system by presenting lipid antigens to T lymphocytes, which is essential for the recognition of lipid-based pathogens and the activation of specific immune responses. CD1B is primarily located on the surface of various immune cells, including cortical thymocytes, Langerhans cells, and certain dendritic cells, highlighting its importance in immune surveillance and response. CD1B interaction with β-2-Microglobulin is vital for stability and function, and CD1B trafficking is regulated by adaptor-protein complexes and CD1-associated chaperones, ensuring proper antigen presentation. Additionally, constitutive endocytosis of CD1B and differential sorting during dendritic cell maturation are critical for separating peptide- and lipid antigen-presenting pathways, further emphasizing CD1B′s role in immune regulation. Human CD1 genes are closely linked in a cluster located at chromosome 1q 22-23, underscoring their evolutionary significance and functional interdependence.

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CD1B Antibody (O249) References:

1. New insights into pathways for CD1-mediated antigen presentation.  |  Sugita, M., et al. 2004. Curr Opin Immunol. 16: 90-5. PMID: 14734115
2. CD1: antigen presentation and T cell function.  |  Brigl, M. and Brenner, MB. 2004. Annu Rev Immunol. 22: 817-90. PMID: 15032598
3. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c.  |  Martin, LH., et al. 1987. Proc Natl Acad Sci U S A. 84: 9189-93. PMID: 2447586
4. Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.  |  Aruffo, A. and Seed, B. 1989. J Immunol. 143: 1723-30. PMID: 2701945
5. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules.  |  Longley, J., et al. 1989. J Invest Dermatol. 92: 628-31. PMID: 2784820
6. The CD1 family: a third lineage of antigen-presenting molecules.  |  Porcelli, SA. 1995. Adv Immunol. 59: 1-98. PMID: 7484459
7. Surface antigens of human thymocyte populations defined by CD3, CD4 and CD8 expression: CD1a is expressed by mature thymocytes but not peripheral T cells.  |  Sotzik, F., et al. 1993. Immunol Lett. 36: 101-6. PMID: 7688345
8. Class I-like CD1A-C do not protect target cells from NK-mediated cytolysis.  |  Storkus, WJ., et al. 1996. Cell Immunol. 167: 154-6. PMID: 8548840
9. Antigen presentation by CD1 and MHC-encoded class I-like molecules.  |  Melián, A., et al. 1996. Curr Opin Immunol. 8: 82-8. PMID: 8729450
10. Analysis of the requirement for beta 2-microglobulin for expression and formation of human CD1 antigens.  |  Bauer, A., et al. 1997. Eur J Immunol. 27: 1366-73. PMID: 9209486

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD1B Antibody (O249) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CD1B Antibody (O249) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD1B Antibody (O249) Specifications

Alternate Product Name: CD1B

Product Clone Name: O249

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CD1B

Epitope Species: human

Product Reactivity/Detection: CD1B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CD1B Antibody (O249): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin