CD175s Antibody (3H1951): sc-70558

CD175s Antibody (3H1951) is a mouse monoclonal IgG1 antibody that detects CD175s in human samples through immunofluorescence (IF) applications. CD175s, also known as sialyl-Tn, is a mucin-type carbohydrate predominantly found in the goblet cells of the small and large bowel, where CD175s plays a crucial role in the initial stages of the mucin biosynthetic pathway. CD175s is essential for the glycosylation of proteins, which significantly influences cell-cell interactions, interactions with the extracellular matrix, and the functionality of intracellular molecules. Notably, CD175s facilitates the transfer of sialic acid, specifically N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage onto O-linked GalNAc residues, a modification that is vital for proper cellular communication and signaling. CD175s has been associated with hyperplasia in squamous epithelium and may serve as a biomarker for tumor regression, making anti-CD175s antibody (3H1951) a valuable tool for predicting the aggressiveness of carcinomas, particularly in breast and ovarian cancers. With specificity and reliability, CD175s monoclonal antibody (3H1951) is an indispensable resource for researchers investigating the role of glycosylation in cancer biology and other related fields.

The preferred CD175s antibody is CD175s Antibody (BRIC111): sc-58970.