CD175s Antibody (BRIC111): sc-58970
- CD175s Antibody (BRIC111) is a mouse monoclonal IgG1 κ CD175s antibody provided at 200 µg/ml
- raised against CD175s red blood cells of human origin
- CD175s Antibody (BRIC111) is recommended for detection of CD175 on Glycophorin A and Glycophorin B in erythrocytes of human origin by IF
- Anti-CD175s Antibody (BRIC111) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD175s Antibody (BRIC111). These reagents are now offered in bundles with CD175s Antibody (BRIC111) (see ordering information below).
QUICK LINKS
CD175s Antibody (BRIC111) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD175s protein of human origin by immunofluorescence (IF). Anti-CD175s antibody (BRIC111) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD175s protein, also known as sialyl-Tn, is a mucin-type carbohydrate predominantly found in goblet cells of the small and large intestine. CD175s plays a crucial role in the initial stages of the mucin biosynthetic pathway, significantly influencing glycosylation of proteins essential for cell-cell interactions, extracellular matrix interactions, and functionality of intracellular molecules. CD175s is responsible for transferring sialic acid, specifically N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage onto O-linked GalNAc residues, which is vital for proper cellular communication and signaling. CD175s has been associated with hyperplasia in squamous epithelium and may serve as a biomarker for tumor regression, making CD175s a valuable tool for predicting aggressiveness of carcinomas, particularly in breast and ovarian cancers.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD175s Antibody (BRIC111) References:
- Differences in sialyl-Tn antigen expression between keratoacanthomas and cutaneous squamous cell carcinomas. | Jensen, P., et al. 1999. J Cutan Pathol. 26: 183-9. PMID: 10335895
- Expression of sialyl-Tn, Tn and T antigens in primary liver cancer. | Sasaki, M., et al. 1999. Pathol Int. 49: 325-31. PMID: 10365852
- Sialyl Tn is a frequently expressed antigen in colorectal cancer: No correlation with patient prognosis. | Lundin, M., et al. 1999. Oncology. 57: 70-6. PMID: 10394128
- [Sialyl Tn antigen]. | Kannagi, R. 1999. Nihon Rinsho. 57 Suppl: 482-7. PMID: 10778170
- Sialyl-Tn- and neuron-specific enolase-positive minimally differentiated erythroleukemia. | Muroi, K., et al. 2000. Intern Med. 39: 843-6. PMID: 11030212
- Immunohistochemical expression of T, Tn and sialyl-Tn antigens and clinical outcome in human breast carcinoma. | Imai, J., et al. 2001. Anticancer Res. 21: 1327-34. PMID: 11396208
- The immunoexpression of Tn, sialyl-Tn and T antigens in chronic active gastritis in relation to Helicobacter pylori infection. | Barresi, G., et al. 2001. Pathology. 33: 298-302. PMID: 11523928
- Establishment and characterization of a new erythroblastic leukemia cell line, EEB: phosphatidylglucoside-mediated erythroid differentiation and apoptosis. | Kawano-Yamamoto, C., et al. 2006. Leuk Res. 30: 829-39. PMID: 16332389
- Mucin carbohydrate antigens (T, Tn, and sialyl-Tn) in human ovarian carcinomas: relationship with histopathology and prognosis. | Ghazizadeh, M., et al. 1997. Hum Pathol. 28: 960-6. PMID: 9269833
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD175s Antibody (BRIC111) | sc-58970 | 200 µg/ml | $322.00 | |||
CD175s Antibody (BRIC111): m-IgG Fc BP-HRP Bundle | sc-526920 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD175s Antibody (BRIC111): m-IgG1 BP-HRP Bundle | sc-532293 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD175s Antibody (BRIC111) AC | sc-58970 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD175s Antibody (BRIC111) HRP | sc-58970 HRP | 200 µg/ml | $322.00 | |||
CD175s Antibody (BRIC111) FITC | sc-58970 FITC | 200 µg/ml | $336.00 | |||
CD175s Antibody (BRIC111) PE | sc-58970 PE | 200 µg/ml | $349.00 | |||
CD175s Antibody (BRIC111) Alexa Fluor® 488 | sc-58970 AF488 | 200 µg/ml | $364.00 | |||
CD175s Antibody (BRIC111) Alexa Fluor® 546 | sc-58970 AF546 | 200 µg/ml | $364.00 | |||
CD175s Antibody (BRIC111) Alexa Fluor® 594 | sc-58970 AF594 | 200 µg/ml | $364.00 | |||
CD175s Antibody (BRIC111) Alexa Fluor® 647 | sc-58970 AF647 | 200 µg/ml | $364.00 | |||
CD175s Antibody (BRIC111) Alexa Fluor® 680 | sc-58970 AF680 | 200 µg/ml | $364.00 | |||
CD175s Antibody (BRIC111) Alexa Fluor® 790 | sc-58970 AF790 | 200 µg/ml | $364.00 |