CD164 Antibody (H-4): sc-271179

CD164 Antibody (H-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects CD164 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD164 (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD164 is a mucin-like cell surface glycoprotein that plays a crucial role in the adhesion of CD34+ cells, acting as a negative regulator of hematopoietic progenitor cell proliferation, which is vital for maintaining proper blood cell development and function. Notably, human CD164 is localized primarily in endosomes and lysosomes within CD34(+)CD38(+) hematopoietic progenitor and epithelial cell lines, with lower concentrations found at the cell surface. This localization suggests a role in intracellular signaling and trafficking, impacting how these cells respond to their environment and regulate hematopoiesis.

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CD164 Antibody (H-4) References:

1. CD164--a novel sialomucin on CD34+ cells.  |  Watt, SM. and Chan, JY. 2000. Leuk Lymphoma. 37: 1-25. PMID: 10721766
2. CD164 as a Basophil Activation Marker.  |  Wolanczyk-Medrala, A., et al. 2011. Curr Pharm Des. 17: 3786-96. PMID: 22103850
3. CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis.  |  Huang, AF., et al. 2013. Mol Cancer. 12: 115. PMID: 24094005
4. CD164 identifies CD4+ T cells highly expressing genes associated with malignancy in Sézary syndrome: the Sézary signature genes, FCRL3, Tox, and miR-214.  |  Benoit, BM., et al. 2017. Arch Dermatol Res. 309: 11-19. PMID: 27766406
5. CD164 regulates proliferation and apoptosis by targeting PTEN in human glioma.  |  Tu, M., et al. 2017. Mol Med Rep. 15: 1713-1721. PMID: 28259931
6. CD164 promotes lung tumor-initiating cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signaling.  |  Chen, WL., et al. 2017. Oncotarget. 8: 54115-54135. PMID: 28903328
7. CD164 promotes tumor progression and predicts the poor prognosis of bladder cancer.  |  Zhang, XG., et al. 2018. Cancer Med. 7: 3763-3772. PMID: 30022623
8. CD164 regulates proliferation, progression, and invasion of human glioblastoma cells.  |  Wang, CC., et al. 2019. Oncotarget. 10: 2041-2054. PMID: 31007847
9. CD164 is a host factor for lymphocytic choriomeningitis virus entry.  |  Bakkers, MJG., et al. 2022. Proc Natl Acad Sci U S A. 119: e2119676119. PMID: 35235462
10. Update on CD164 and LMX1A genes to strengthen their causative role in autosomal dominant hearing loss.  |  Oziębło, D., et al. 2022. Hum Genet. 141: 445-453. PMID: 35254497
11. Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.  |  Kar, SP., et al. 2022. Nat Genet. 54: 1155-1166. PMID: 35835912
12. CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21.  |  Watt, SM., et al. 1998. Blood. 92: 849-66. PMID: 9680353

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD164 Antibody (H-4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-CD164 Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD164 Antibody (H-4) Specifications

Alternate Product Name: CD164

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-123

Epitope Target: CD164

Epitope Species: human

Product Reactivity/Detection: CD164

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for CD164 Antibody (H-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin