CD161 Antibody (HP-3G10): sc-69891
- CD161 Antibody (HP-3G10) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- raised against NK cells of human origin
- recommended for detection of CD161 of human origin by WB and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD161 Antibody (HP-3G10). This work is in progress.
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CD161 Antibody (HP-3G10) is a mouse monoclonal IgG1 antibody that detects CD161 in human samples through applications such as western blotting (WB) and flow cytometry (FCM). CD161, also known as the natural killer cell receptor, plays a crucial role in the immune response by mediating the activation of natural killer (NK) cells and a subset of CD8+ T cells, which are essential for targeting and eliminating infected or malignant cells. CD161 expression on immune cells indicates cytotoxic potential, particularly in conditions such as psoriasis, where CD161 expression is upregulated. This upregulation is notably influenced by interleukin-12 (IL-12), a cytokine that enhances CD161 transcription and surface expression, thereby promoting the proliferation and activation of cytotoxic effector T cells. Understanding CD161 function is vital, as CD161 not only serves as a marker for NK cells but also provides insights into the mechanisms of immune regulation and potential therapeutic targets in various diseases. Anti-CD161 antibody (HP-3G10) is an invaluable tool for researchers investigating the dynamics of immune cell activation and the underlying pathways involved in immune responses.
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CD161 Antibody (HP-3G10) References:
- Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161. | Bai, A. and Robson, S. 2015. Purinergic Signal. 11: 317-9. PMID: 26059452
- The prognostic landscape of genes and infiltrating immune cells across human cancers. | Gentles, AJ., et al. 2015. Nat Med. 21: 938-945. PMID: 26193342
- CD8+CD161+ T-Cells: Cytotoxic Memory Cells With High Therapeutic Potential. | Konduri, V., et al. 2020. Front Immunol. 11: 613204. PMID: 33597948
- CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors. | Duurland, CL., et al. 2022. J Immunother Cancer. 10: PMID: 35039463
- CD161 expression defines new human γδ T cell subsets. | Karunathilaka, A., et al. 2022. Immun Ageing. 19: 11. PMID: 35193613
- Increased Non-MAIT CD161+CD8+ T Cells Display Pathogenic Potential in Chronic HBV Infection. | Liu, Y., et al. 2023. Cell Mol Gastroenterol Hepatol. 15: 1181-1198. PMID: 36787843
- Cytotoxic CD161-CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus. | Xiong, H., et al. 2023. EBioMedicine. 90: 104507. PMID: 36893588
- MCAM+CD161- Th17 Subset Expressing CD83 Enhances Tc17 Response in Psoriasis. | Maeda, K., et al. 2023. J Immunol. 210: 1867-1881. PMID: 37186262
- Targeting of the CD161 inhibitory receptor enhances T-cell-mediated immunity against hematological malignancies. | Alvarez Calderon, F., et al. 2024. Blood. 143: 1124-1138. PMID: 38153903
- Targeting CD161 in B-cell malignancies. | Blunt, MD. 2024. Blood. 143: 1061-1062. PMID: 38512265
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD161 Antibody (HP-3G10) | sc-69891 | 200 µg/ml | $322.00 | |||
CD161 Antibody (HP-3G10) FITC | sc-69891 FITC | 200 µg/ml | $336.00 | |||
CD161 Antibody (HP-3G10) PE | sc-69891 PE | 200 µg/ml | $349.00 |