CD161 Antibody (B199.2): sc-58963

CD161 Antibody (B199.2) is a mouse monoclonal IgG2b antibody that detects CD161 of human origin by immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-CD161 antibody (B199.2) is available as a non-conjugated monoclonal isotype antibody. CD161 (B199.2) monoclonal antibody recognizes natural killer cell receptor 1 (NKR-P1A), which plays a crucial role in immune response by mediating the activation of natural killer (NK) cells and a subset of T cells. NKR-P1A is primarily located on the surface of NK cells and a specific population of CD8+ T cells, where CD161 functions as an activating receptor that enhances cytotoxic activity against infected or malignant cells. NKR-P1A on these immune cells serves as a marker for cytotoxic effector T cells, which expand following antigenic activation, leading to robust immune responses. CD161 expression is notably upregulated by interleukin-12 (IL-12), a cytokine that promotes the differentiation and activation of T cells and NK cells, highlighting NKR-P1A′s importance in orchestrating effective immune responses.

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CD161 Antibody (B199.2) References:

1. Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice.  |  Poulton, LD., et al. 2001. Int Immunol. 13: 887-96. PMID: 11431419
2. MHC class I molecules on adenovirus E1A-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection.  |  Routes, JM., et al. 2001. Int Immunol. 13: 1301-7. PMID: 11581175
3. Pan natural killer cell monoclonal antibodies and their relationship to the NK1.1 antigen.  |  Sentman, CL., et al. 1989. Hybridoma. 8: 605-14. PMID: 2613267
4. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis.  |  Mathewson, ND., et al. 2021. Cell. 184: 1281-1298.e26. PMID: 33592174
5. Clinical characterization and immunosuppressive regulation of CD161 (KLRB1) in glioma through 916 samples.  |  Di, W., et al. 2022. Cancer Sci. 113: 756-769. PMID: 34881489
6. LLT1-CD161 Interaction in Cancer: Promises and Challenges.  |  Braud, VM., et al. 2022. Front Immunol. 13: 847576. PMID: 35185935
7. The NK-1.1(-) mouse: a model to study differentiation of murine NK cells.  |  Koo, GC., et al. 1986. J Immunol. 137: 3742-7. PMID: 3782794
8. Establishment of monoclonal anti-Nk-1.1 antibody.  |  Koo, GC. and Peppard, JR. 1984. Hybridoma. 3: 301-3. PMID: 6500587
9. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells.  |  Garni-Wagner, BA., et al. 1993. J Immunol. 151: 60-70. PMID: 8326140
10. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex.  |  Yokoyama, WM. and Seaman, WE. 1993. Annu Rev Immunol. 11: 613-35. PMID: 8476574
11. Mouse NK1.1+ T cells: a new family of T cells.  |  Vicari, AP. and Zlotnik, A. 1996. Immunol Today. 17: 71-6. PMID: 8808053
12. Natural killer cell proliferation induced by anti-NK1.1 and IL-2.  |  Reichlin, A. and Yokoyama, WM. 1998. Immunol Cell Biol. 76: 143-52. PMID: 9619484

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD161 Antibody (B199.2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CD161 Antibody (B199.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD161 Antibody (B199.2) Specifications

Alternate Product Name: CD161

Product Clone Name: B199.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: CD161

Epitope Species: human

Product Reactivity/Detection: CD161 cell surface antigen

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CD161 Antibody (B199.2): N/A