CD154 Antibody (B-4): sc-74447

CD154 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects CD154 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD154, also known as CD40 ligand, plays a crucial role in the immune response by facilitating communication between T cells and B cells, which is essential for effective antibody production. Anti-CD154 antibody (B-4) recognizes CD154 primarily located on the surface of activated T cells, where CD154 interacts with CD40 on B cells, triggering a cascade of signaling events that lead to B cell activation, proliferation, and differentiation into antibody-secreting plasma cells. CD154 not only promotes immunoglobulin class switching but also enhances the overall adaptive immune response. Dysregulation of CD154 expression can lead to various immunological disorders, including hyper-IgM immunodeficiency syndrome type 1, highlighting CD154′s significance in maintaining immune homeostasis. CD154 monoclonal antibody (B-4) serves as an invaluable tool for researchers studying immune responses and related pathologies, providing insights into the mechanisms of T cell and B cell interactions.

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CD154 Antibody (B-4) References:

1. The role of CD154 in organ transplant rejection and acceptance.  |  Kirk, AD., et al. 2001. Philos Trans R Soc Lond B Biol Sci. 356: 691-702. PMID: 11375072
2. The role of CD40 and CD154/CD40L in dendritic cells.  |  Ma, DY. and Clark, EA. 2009. Semin Immunol. 21: 265-72. PMID: 19524453
3. The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis.  |  Engel, D., et al. 2009. Semin Immunol. 21: 308-12. PMID: 19616449
4. CD40 ligand (CD154) involvement in platelet transfusion reactions.  |  Sahler, J., et al. 2012. Transfus Clin Biol. 19: 98-103. PMID: 22703674
5. Interaction of CD154 with different receptors and its role in bidirectional signals.  |  Alturaihi, H., et al. 2015. Eur J Immunol. 45: 592-602. PMID: 25403978
6. CD154 Induces Matrix Metalloproteinase-9 Secretion in Human Podocytes.  |  Rigothier, C., et al. 2016. J Cell Biochem. 117: 2737-2747. PMID: 27070919
7. A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation.  |  Villeneuve, J., et al. 2017. Mediators Inflamm. 2017: 2982879. PMID: 28785137
8. Multiple Sclerosis CD49d+CD154+ As Myelin-Specific Lymphocytes Induced During Remyelination.  |  Piatek, P., et al. 2019. Cells. 9: PMID: 31861635
9. CD11b is a novel alternate receptor for CD154 during alloimmunity.  |  Liu, D. and Ford, ML. 2020. Am J Transplant. 20: 2216-2225. PMID: 32149455
10. CD154 Resistant to Cleavage from Intracellular Milieu and Cell Surface Induces More Potent CD40-Mediated Responses.  |  Salti, S., et al. 2021. J Immunol. 206: 1793-1805. PMID: 33762325

The preferred CD154 antibody is CD154 Antibody (F-1): sc-374635.