CD137L Antibody (G-10): sc-398933

CD137L Antibody (G-10) is a mouse monoclonal IgM antibody that detects CD137L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CD137L antibody (G-10) is available as the non-conjugated form. CD137L protein, also known as 4-1BB ligand, plays a crucial role in the immune system by providing a costimulatory signal necessary for T cell activation and proliferation. CD137L is primarily expressed on antigen-presenting cells, such as B cells, macrophages, and dendritic cells, and interacts with CD137, which is found on activated T cells. This interaction enhances immune response, particularly in tumor immunity and chronic infections. Additionally, CD137L binding to CD137 can lead to apoptosis induction in resting lymphocytes, while promoting peripheral monocyte survival through specific cytokine release. Soluble forms of CD137L have been detected in sera of patients with autoimmune conditions like rheumatoid arthritis, suggesting a potential regulatory role in modulating immune responses. CD137L′s influence on both T cell activation and monocyte survival underscores its importance in maintaining immune homeostasis and potential as a therapeutic target in immunological diseases.

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CD137L Antibody (G-10) References:

1. Identification of CD137 as a potent monocyte survival factor.  |  Langstein, J. and Schwarz, H. 1999. J Leukoc Biol. 65: 829-33. PMID: 10380906
2. CD137-induced apoptosis is independent of CD95.  |  Michel, J., et al. 1999. Immunology. 98: 42-6. PMID: 10469232
3. CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes.  |  Kienzle, G. and von Kempis, J. 2000. Int Immunol. 12: 73-82. PMID: 10607752
4. Co-stimulation of antigen-specific CD4 T cells by 4-1BB ligand.  |  Gramaglia, I., et al. 2000. Eur J Immunol. 30: 392-402. PMID: 10671194
5. Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes.  |  Michel, J. and Schwarz, H. 2000. Cytokine. 12: 742-6. PMID: 10843756
6. 4-1BB: still in the midst of darkness.  |  Kwon, B., et al. 2000. Mol Cells. 10: 119-26. PMID: 10850651
7. Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation.  |  Langstein, J., et al. 2000. Biochem Biophys Res Commun. 273: 117-22. PMID: 10873573

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD137L Antibody (G-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CD137L Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD137L Antibody (G-10) Specifications

Alternate Product Name: CD137L

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 41-67

Epitope Target: CD137L

Epitope Species: mouse

Product Reactivity/Detection: CD137L

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CD137L Antibody (G-10): P: Blocking Peptide