CD-MPR Antibody (H-7): sc-365196
- CD-MPR Antibody (H-7) is a mouse monoclonal IgG1 κ CD-MPR antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 27-277 mapping at the C-terminus of CD-MPR of human origin
- CD-MPR Antibody (H-7) is recommended for detection of CD-MPR of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CD-MPR Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD-MPR Antibody (H-7) for WB applications. These reagents are now offered in bundles with CD-MPR Antibody (H-7) (see ordering information below).
QUICK LINKS
SEE ALSO...
CD-MPR Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD-MPR of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD-MPR (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD-MPR, or cation-dependent mannose-6-phosphate receptor, is an oligomeric transmembrane protein essential for intracellular transport of phosphorylated lysosomal enzymes from trans-Golgi network to lysosomes, ensuring proper cellular function and enzyme activity. CD-MPR′s unique structure includes a 67 amino acid cytoplasmic tail containing sorting signals crucial for preventing degradation in lysosomes, thereby maintaining availability for enzyme delivery. CD-MPR is predominantly expressed in mouse testicular germ cells and exhibits differentiated expression during rat spermatozoa maturation. Notably, increased expression of CD-MPR has been observed in Alzheimer′s disease, and CD-MPR′s gene is located adjacent to a chromosomal region potentially linked to the disease, suggesting a significant role in neurodegenerative processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD-MPR Antibody (H-7) References:
- Mutational analysis of the binding site residues of the bovine cation-dependent mannose 6-phosphate receptor. | Olson, LJ., et al. 1999. J Biol Chem. 274: 36905-11. PMID: 10601243
- Changes in distribution of phosphomannosyl receptors during maturation of rat spermatozoa. | Belmonte, SA., et al. 2000. Biol Reprod. 63: 1172-8. PMID: 10993842
- Targeted disruption of the cation-dependent or cation-independent mannose 6-phosphate receptor does not decrease the content of acid glycosidases in the acrosome. | Chayko, CA. and Orgebin-Crist, MC. 2000. J Androl. 21: 944-53. PMID: 11105922
- The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes. | Stöckli, J. and Rohrer, J. 2004. Mol Biol Cell. 15: 2617-26. PMID: 15034140
- The acidic cluster of the CK2 site of the cation-dependent mannose 6-phosphate receptor (CD-MPR) but not its phosphorylation is required for GGA1 and AP-1 binding. | Stöckli, J., et al. 2004. J Biol Chem. 279: 23542-9. PMID: 15044437
- Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease. | Kölsch, H., et al. 2004. Psychiatr Genet. 14: 97-100. PMID: 15167696
- Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptor. | Reddy, ST., et al. 2004. J Biol Chem. 279: 38658-67. PMID: 15252023
- Ligand binding specificities of the two mannose 6-phosphate receptors. | Sleat, DE. and Lobel, P. 1997. J Biol Chem. 272: 731-8. PMID: 8995357
- Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail. | Schweizer, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 14471-6. PMID: 9405637
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD-MPR Antibody (H-7) | sc-365196 | 200 µg/ml | $316.00 | |||
CD-MPR Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-529323 | 200 µg Ab; 10 µg BP | $354.00 | |||
CD-MPR Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-522159 | 200 µg Ab, 40 µg BP | $354.00 | |||
CD-MPR Antibody (H-7) AC | sc-365196 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CD-MPR Antibody (H-7) HRP | sc-365196 HRP | 200 µg/ml | $316.00 | |||
CD-MPR Antibody (H-7) FITC | sc-365196 FITC | 200 µg/ml | $330.00 | |||
CD-MPR Antibody (H-7) PE | sc-365196 PE | 200 µg/ml | $343.00 | |||
CD-MPR Antibody (H-7) Alexa Fluor® 488 | sc-365196 AF488 | 200 µg/ml | $357.00 | |||
CD-MPR Antibody (H-7) Alexa Fluor® 546 | sc-365196 AF546 | 200 µg/ml | $357.00 | |||
CD-MPR Antibody (H-7) Alexa Fluor® 594 | sc-365196 AF594 | 200 µg/ml | $357.00 | |||
CD-MPR Antibody (H-7) Alexa Fluor® 647 | sc-365196 AF647 | 200 µg/ml | $357.00 | |||
CD-MPR Antibody (H-7) Alexa Fluor® 680 | sc-365196 AF680 | 200 µg/ml | $357.00 | |||
CD-MPR Antibody (H-7) Alexa Fluor® 790 | sc-365196 AF790 | 200 µg/ml | $357.00 |