CCRK Antibody (L-35): sc-81838

CCRK Antibody (L-35) is a mouse monoclonal IgG2a antibody that detects CCRK in human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CCRK, also known as p42 or CDCH, is a 346 amino acid nuclear protein that plays a crucial role in regulating cell growth by catalytically phosphorylating the Thr 160 residue on cyclin-dependent kinase 2 (Cdk2), thereby activating Cdk2 and facilitating cell cycle progression. This function positions CCRK as a potential oncogene in various carcinomas, including glioblastoma multiforme, an aggressive primary brain tumor. CCRK overexpression has been linked to increased tumor growth rates in glioblastoma, while suppression reduces these rates, underscoring CCRK′s significance in tumor biology. CCRK exists as a monomer and is expressed in three different isoforms due to alternative splicing, which may contribute to functional diversity and regulatory mechanisms in cellular processes. Anti-CCRK antibody (L-35) serves as an essential tool for researchers investigating CCRK′s role in cancer and cell cycle regulation.