CCRK Antibody (885CT27.1.1): sc-517320

CCRK Antibody (885CT27.1.1) is a mouse monoclonal IgG1 antibody that detects CCRK protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-CCRK antibody (885CT27.1.1) is available as the non-conjugated monoclonal isotype antibody. CCRK, also known as cell cycle related kinase, p42, or CDCH, is a crucial 346 amino acid nuclear protein that plays a significant role in regulating cell growth and cell cycle. CCRK is primarily located in the nucleus, where CCRK catalytically phosphorylates the Thr 160 residue on cyclin-dependent kinase 2 (Cdk2), a key player in cell cycle progression. This phosphorylation event activates Cdk2, allowing the cell cycle to move forward, which is essential for normal cellular function and division. Dysregulation of CCRK has been implicated in various carcinomas, including glioblastoma multiforme, an aggressive brain tumor, where CCRK overexpression correlates with increased tumor growth rates. CCRK′s ability to influence cell cycle events positions CCRK as a potential oncogene, making CCRK a target of interest for cancer research. Additionally, CCRK exists as a monomer and is expressed in three different isoforms due to alternative splicing, which may contribute to CCRK′s functional diversity and regulatory mechanisms in different cellular contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CCRK Antibody (885CT27.1.1) References:

1. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.  |  Liu, Y., et al. 2004. J Biol Chem. 279: 4507-14. PMID: 14597612
2. A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression.  |  Caligiuri, M., et al. 2005. Chem Biol. 12: 1103-15. PMID: 16242653
3. The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity.  |  Wohlbold, L., et al. 2006. Cell Cycle. 5: 546-54. PMID: 16552187
4. CDK2-activating kinase (CAK): more questions than answers.  |  Abbas, T. and Dutta, A. 2006. Cell Cycle. 5: 1123-4. PMID: 16687928
5. Cell cycle-related kinase: a novel candidate oncogene in human glioblastoma.  |  Ng, SS., et al. 2007. J Natl Cancer Inst. 99: 936-48. PMID: 17565152