CCM3 Antibody (F-12): sc-365587
- CCM3 Antibody (F-12) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 3-191 mapping within an internal region of CCM3 of human origin
- Anti-CCM3 Antibody (F-12) is recommended for detection of CCM3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CCM3 Antibody (F-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CCM3 Antibody (F-12) for WB applications. These reagents are now offered in bundles with CCM3 Antibody (F-12) (see ordering information below).
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CCM3 Antibody (F-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects CCM3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CCM3 (F-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCM3, also known as Pdcd-10, plays a crucial role in the regulation of programmed cell death, which is vital for processes such as embryogenesis, tissue turnover, and the proper functioning of the immune system. Located primarily in the cytoplasm, CCM3 interacts with key signaling pathways, particularly the ERK pathway, where CCM3 positively regulates MST4, thereby promoting cell growth and differentiation. This regulation is essential for vascular development and maturation, and defects in CCM3 can lead to cerebral cavernous malformations 3, a condition characterized by vascular anomalies in the central nervous system that may result in severe complications such as stroke, seizures, and focal hemorrhages. CCM3 (F-12) monoclonal antibody in various formats enhances research and diagnostic applications, making anti-CCM3 antibody (F-12) an invaluable tool for studying the mechanisms of apoptosis and vascular biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCM3 Antibody (F-12) References:
- CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. | Voss, K., et al. 2007. Neurogenetics. 8: 249-56. PMID: 17657516
- CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. | Fidalgo, M., et al. 2010. J Cell Sci. 123: 1274-84. PMID: 20332113
- Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations. | Zhu, Y., et al. 2010. Neurosurg Focus. 29: E1. PMID: 20809750
- Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations. | You, C., et al. 2013. J Cell Mol Med. 17: 407-18. PMID: 23388056
- Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. | Louvi, A., et al. 2014. Development. 141: 1404-15. PMID: 24595293
- CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. | Draheim, KM., et al. 2015. J Cell Biol. 208: 987-1001. PMID: 25825518
- Expression of CCM2 and CCM3 during mouse gonadogenesis. | Yaba, A., et al. 2015. J Assist Reprod Genet. 32: 1497-507. PMID: 26386873
- Biallelic CCM3 mutations cause a clonogenic survival advantage and endothelial cell stiffening. | Schwefel, K., et al. 2019. J Cell Mol Med. 23: 1771-1783. PMID: 30549232
- Knockdown of CCM3 promotes angiogenesis through activation and nuclear translocation of YAP/TAZ. | Tang, L., et al. 2024. Biochem Biophys Res Commun. 701: 149525. PMID: 38320423
- PDCD10/CCM3, a potential target for pancreatic ductal adenocarcinoma? | Ungefroren, H. 2025. Clin Sci (Lond). 139: PMID: 39927779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCM3 Antibody (F-12) | sc-365587 | 200 µg/ml | $322.00 | |||
CCM3 Antibody (F-12): m-IgG Fc BP-HRP Bundle | sc-529396 | 200 µg Ab; 10 µg BP | $361.00 | |||
CCM3 Antibody (F-12): m-IgGκ BP-HRP Bundle | sc-522276 | 200 µg Ab, 40 µg BP | $361.00 | |||
CCM3 Antibody (F-12) AC | sc-365587 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CCM3 Antibody (F-12) HRP | sc-365587 HRP | 200 µg/ml | $322.00 | |||
CCM3 Antibody (F-12) FITC | sc-365587 FITC | 200 µg/ml | $336.00 | |||
CCM3 Antibody (F-12) PE | sc-365587 PE | 200 µg/ml | $349.00 | |||
CCM3 Antibody (F-12) Alexa Fluor® 488 | sc-365587 AF488 | 200 µg/ml | $364.00 | |||
CCM3 Antibody (F-12) Alexa Fluor® 546 | sc-365587 AF546 | 200 µg/ml | $364.00 | |||
CCM3 Antibody (F-12) Alexa Fluor® 594 | sc-365587 AF594 | 200 µg/ml | $364.00 | |||
CCM3 Antibody (F-12) Alexa Fluor® 647 | sc-365587 AF647 | 200 µg/ml | $364.00 | |||
CCM3 Antibody (F-12) Alexa Fluor® 680 | sc-365587 AF680 | 200 µg/ml | $364.00 | |||
CCM3 Antibody (F-12) Alexa Fluor® 790 | sc-365587 AF790 | 200 µg/ml | $364.00 |