CCL27 Antibody (G-6): sc-390112
- CCL27 Antibody (G-6) is a mouse monoclonal IgG1 κ CCL27 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 85-109 at the C-terminus of CCL27 of human origin
- CCL27 Antibody (G-6) is recommended for detection of CCL27 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-CCL27 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CCL27 Antibody (G-6) for WB applications. These reagents are now offered in bundles with CCL27 Antibody (G-6) (see ordering information below).
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CCL27 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CCL27 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CCL27 Antibody (G-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCL27, also known as cutaneous T cell-attracting chemokine, CTACK, ILC, ALP, and skinkine, plays a crucial role in skin homeostasis and inflammatory response by binding to chemokine receptor CCR10 (GPR-2). This interaction facilitates preferential migration and recruitment of cutaneous lymphocyte-associated antigen (CLA)+ memory lymphocytes to the skin, which is essential for maintaining immune surveillance and responding to skin inflammation. CCL27 is predominantly expressed in human keratinocytes and mouse epidermis, while CCR10 is found in various skin cells, including melanocytes, dermal fibroblasts, dermal microvascular endothelial cells, and T cells, as well as skin-derived Langerhans cells. The ability of CCL27 to attract specific immune cells underscores CCL27′s importance in both normal skin function and pathological conditions, making anti-CCL27 antibody (G-6) a valuable tool for researchers studying skin-related immune responses and disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCL27 Antibody (G-6) References:
- Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension. | Hromas, R., et al. 1999. Biochem Biophys Res Commun. 258: 737-40. PMID: 10329455
- Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. | Ishikawa-Mochizuki, I., et al. 1999. FEBS Lett. 460: 544-8. PMID: 10556532
- CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. | Morales, J., et al. 1999. Proc Natl Acad Sci U S A. 96: 14470-5. PMID: 10588729
- Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). | Homey, B., et al. 2000. J Immunol. 164: 3465-70. PMID: 10725697
- Chemokines and leukocyte traffic. | Baggiolini, M. 1998. Nature. 392: 565-8. PMID: 9560152
- Recent advances in chemokines and chemokine receptors. | Zlotnik, A., et al. 1999. Crit Rev Immunol. 19: 1-47. PMID: 9987599
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCL27 Antibody (G-6) | sc-390112 | 200 µg/ml | $316.00 | |||
CCL27 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-530066 | 200 µg Ab; 10 µg BP | $354.00 | |||
CCL27 Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-523410 | 200 µg Ab, 40 µg BP | $354.00 | |||
CCL27 Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-543851 | 200 µg Ab; 20 µg BP | $354.00 | |||
CCL27 Antibody (G-6) AC | sc-390112 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CCL27 Antibody (G-6) HRP | sc-390112 HRP | 200 µg/ml | $316.00 | |||
CCL27 Antibody (G-6) FITC | sc-390112 FITC | 200 µg/ml | $330.00 | |||
CCL27 Antibody (G-6) PE | sc-390112 PE | 200 µg/ml | $343.00 | |||
CCL27 Antibody (G-6) Alexa Fluor® 488 | sc-390112 AF488 | 200 µg/ml | $357.00 | |||
CCL27 Antibody (G-6) Alexa Fluor® 546 | sc-390112 AF546 | 200 µg/ml | $357.00 | |||
CCL27 Antibody (G-6) Alexa Fluor® 594 | sc-390112 AF594 | 200 µg/ml | $357.00 | |||
CCL27 Antibody (G-6) Alexa Fluor® 647 | sc-390112 AF647 | 200 µg/ml | $357.00 | |||
CCL27 Antibody (G-6) Alexa Fluor® 680 | sc-390112 AF680 | 200 µg/ml | $357.00 | |||
CCL27 Antibody (G-6) Alexa Fluor® 790 | sc-390112 AF790 | 200 µg/ml | $357.00 | |||
CCL27 (G-6) Neutralizing Peptide | sc-390112 P | 100 µg/0.5 ml | $68.00 |