CCDC98 Antibody (A-3): sc-376951
- CCDC98 Antibody (A-3) is a mouse monoclonal IgG1 κ CCDC98 antibody provided at 200 µg/ml
- raised against amino acids 33-132 mapping within an internal region of CCDC98 of human origin
- CCDC98 Antibody (A-3) is recommended for detection of CCDC98 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CCDC98 Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CCDC98 Antibody (A-3) for WB and IHC(P) applications. These reagents are now offered in bundles with CCDC98 Antibody (A-3) (see ordering information below).
CCDC98 Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects CCDC98 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CCDC98 Antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Coiled-coil domain-containing protein 98 (CCDC98), also known as FAM175A and ABRA1, is a 409 amino acid protein that plays a crucial role in DNA repair by interacting with breast cancer-1 (BRCA1). This interaction is vital as BRCA1 is essential for cellular response to DNA damage, particularly in regulating cell cycle checkpoints during S phase and G2/M transition. CCDC98 acts upstream of BRCA1, modulating BRCA1 activity in a phosphorylation-dependent manner, which is critical for forming BRCA1 foci in response to ionizing radiation. Proper functioning of CCDC98 is therefore important not only for maintaining genomic stability but also for understanding mechanisms underlying breast cancer, making anti-CCDC98 antibody (A-3) an invaluable tool for researchers studying DNA repair pathways and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCDC98 Antibody (A-3) References:
- Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. | Wang, B., et al. 2007. Science. 316: 1194-8. PMID: 17525340
- CCDC98 targets BRCA1 to DNA damage sites. | Liu, Z., et al. 2007. Nat Struct Mol Biol. 14: 716-20. PMID: 17643121
- CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. | Kim, H., et al. 2007. Nat Struct Mol Biol. 14: 710-5. PMID: 17643122
- Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. | Wang, B. and Elledge, SJ. 2007. Proc Natl Acad Sci U S A. 104: 20759-63. PMID: 18077395
- Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility. | Osorio, A., et al. 2009. Breast Cancer Res Treat. 113: 371-6. PMID: 18270812
- New players in the BRCA1-mediated DNA damage responsive pathway. | Kim, H. and Chen, J. 2008. Mol Cells. 25: 457-61. PMID: 18443409
- BRCT domains: phosphopeptide binding and signaling modules. | Rodriguez, MC. and Songyang, Z. 2008. Front Biosci. 13: 5905-15. PMID: 18508631
- RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. | Yan, J. and Jetten, AM. 2008. Cancer Lett. 271: 179-90. PMID: 18550271
- Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases. | Novak, DJ., et al. 2009. Breast Cancer Res Treat. 117: 453-9. PMID: 18695986
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCDC98 Antibody (A-3) | sc-376951 | 200 µg/ml | $322.00 | |||
CCDC98 Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-527558 | 200 µg Ab; 10 µg BP | $361.00 | |||
CCDC98 Antibody (A-3): m-IgG1 BP-HRP Bundle | sc-532931 | 200 µg Ab; 20 µg BP | $361.00 | |||
CCDC98 Antibody (A-3) AC | sc-376951 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CCDC98 Antibody (A-3) HRP | sc-376951 HRP | 200 µg/ml | $322.00 | |||
CCDC98 Antibody (A-3) FITC | sc-376951 FITC | 200 µg/ml | $336.00 | |||
CCDC98 Antibody (A-3) PE | sc-376951 PE | 200 µg/ml | $349.00 | |||
CCDC98 Antibody (A-3) Alexa Fluor® 488 | sc-376951 AF488 | 200 µg/ml | $364.00 | |||
CCDC98 Antibody (A-3) Alexa Fluor® 546 | sc-376951 AF546 | 200 µg/ml | $364.00 | |||
CCDC98 Antibody (A-3) Alexa Fluor® 594 | sc-376951 AF594 | 200 µg/ml | $364.00 | |||
CCDC98 Antibody (A-3) Alexa Fluor® 647 | sc-376951 AF647 | 200 µg/ml | $364.00 | |||
CCDC98 Antibody (A-3) Alexa Fluor® 680 | sc-376951 AF680 | 200 µg/ml | $364.00 | |||
CCDC98 Antibody (A-3) Alexa Fluor® 790 | sc-376951 AF790 | 200 µg/ml | $364.00 |