CCDC116 Antibody (G-5): sc-514528
- CCDC116 Antibody (G-5) is a mouse monoclonal IgG2a κ CCDC116 antibody provided at 200 µg/ml
- raised against amino acids 1-152 mapping at the N-terminus of CCDC116 of human origin
- CCDC116 Antibody (G-5) is recommended for detection of CCDC116 of human origin by WB, IP, IF and ELISA
- Anti-CCDC116 Antibody (G-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CCDC116 Antibody (G-5) for WB applications. These reagents are now offered in bundles with CCDC116 Antibody (G-5) (see ordering information below).
CCDC116 Antibody (G-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects CCDC116 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CCDC116 (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCDC116, also known as coiled-coil domain containing 116, is a 515 amino acid protein that exists in two alternatively spliced isoforms and is encoded by a gene located on human chromosome 22q11.21. CCDC116 plays a crucial role in cellular processes, including gene expression regulation and cellular signaling pathways, which are vital for maintaining cellular homeostasis and responding to environmental stimuli. Notably, CCDC116 has been shown to be induced by curcumin, a compound with potential anti-inflammatory properties, suggesting a protective role in conditions such as inflammatory bowel disease and ulcerative colitis. CCDC116′s significance extends beyond basic functions, as expression alterations have been linked to various genetic disorders associated with chromosome 22, including Phelan-McDermid syndrome and neurofibromatosis type 2, highlighting importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CCDC116 Antibody (G-5) References:
- Disease genes and chromosomes: disease maps of the human genome. Chromosome 22. | Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
- Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2. | Tsilchorozidou, T., et al. 2004. J Med Genet. 41: 529-34. PMID: 15235024
- Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia. | Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
- Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings. | Ahronowitz, I., et al. 2007. Hum Mutat. 28: 1-12. PMID: 16983642
- BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility. | Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
- Deletion 22q11: spectrum of associated disorders. | Hay, BN. 2007. Semin Pediatr Neurol. 14: 136-9. PMID: 17980310
- Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent. | Billerey-Larmonier, C., et al. 2008. Inflamm Bowel Dis. 14: 780-93. PMID: 18200517
- High frequency of submicroscopic genomic aberrations detected by tiling path array comparative genome hybridisation in patients with isolated congenital heart disease. | Erdogan, F., et al. 2008. J Med Genet. 45: 704-9. PMID: 18713793
- Signals of recent positive selection in a worldwide sample of human populations. | Pickrell, JK., et al. 2009. Genome Res. 19: 826-37. PMID: 19307593
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCDC116 Antibody (G-5) | sc-514528 | 200 µg/ml | $316.00 | |||
CCDC116 Antibody (G-5): m-IgG Fc BP-HRP Bundle | sc-531153 | 200 µg Ab; 10 µg BP | $354.00 | |||
CCDC116 Antibody (G-5): m-IgGκ BP-HRP Bundle | sc-524758 | 200 µg Ab, 40 µg BP | $354.00 | |||
CCDC116 Antibody (G-5): m-IgG2a BP-HRP Bundle | sc-547705 | 200 µg Ab; 10 µg BP | $354.00 | |||
CCDC116 Antibody (G-5) AC | sc-514528 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CCDC116 Antibody (G-5) HRP | sc-514528 HRP | 200 µg/ml | $316.00 | |||
CCDC116 Antibody (G-5) FITC | sc-514528 FITC | 200 µg/ml | $330.00 | |||
CCDC116 Antibody (G-5) PE | sc-514528 PE | 200 µg/ml | $343.00 | |||
CCDC116 Antibody (G-5) Alexa Fluor® 488 | sc-514528 AF488 | 200 µg/ml | $357.00 | |||
CCDC116 Antibody (G-5) Alexa Fluor® 546 | sc-514528 AF546 | 200 µg/ml | $357.00 | |||
CCDC116 Antibody (G-5) Alexa Fluor® 594 | sc-514528 AF594 | 200 µg/ml | $357.00 | |||
CCDC116 Antibody (G-5) Alexa Fluor® 647 | sc-514528 AF647 | 200 µg/ml | $357.00 | |||
CCDC116 Antibody (G-5) Alexa Fluor® 680 | sc-514528 AF680 | 200 µg/ml | $357.00 | |||
CCDC116 Antibody (G-5) Alexa Fluor® 790 | sc-514528 AF790 | 200 µg/ml | $357.00 |