CCDC109A Antibody (E-9): sc-515930

CCDC109A Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects CCDC109A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CCDC109A (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CCDC109A, also known as mitochondrial calcium uniporter (MCU), is a crucial 351 amino acid multi-pass membrane protein located in the inner mitochondrial membrane, where CCDC109A plays a vital role in regulating calcium ion transport into mitochondria. This calcium influx is essential for various cellular processes, including energy production, apoptosis, and cellular signaling, highlighting CCDC109A′s importance in maintaining cellular homeostasis and metabolic function. CCDC109A exists as a homooligomer and interacts with calcium binding atopy-related autoantigen 1 (CBARA1), which further underscores CCDC109A′s significance in calcium signaling pathways. CCDC109A is encoded by a gene located on human chromosome 10, a region that harbors over 800 genes and is associated with several critical biological functions and disorders, including tumor suppression and DNA repair mechanisms. Multiple alternatively spliced isoforms of CCDC109A add another layer of complexity to CCDC109A′s functional diversity, making CCDC109A a key target for research in mitochondrial biology and related diseases.

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CCDC109A Antibody (E-9) References:

1. Molecular cell biology of Charcot-Marie-Tooth disease.  |  Berger, P., et al. 2002. Neurogenetics. 4: 1-15. PMID: 12030326
2. Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21.  |  Troelstra, C., et al. 1992. Genomics. 12: 745-9. PMID: 1349298
3. Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.  |  Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
4. First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.  |  Cho, MY., et al. 2008. Am J Surg Pathol. 32: 1258-64. PMID: 18594467
5. PTEN: a new guardian of the genome.  |  Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
6. Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome.  |  Laugel, V., et al. 2010. Hum Mutat. 31: 113-26. PMID: 19894250
7. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.  |  Baughman, JM., et al. 2011. Nature. 476: 341-5. PMID: 21685886
8. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.  |  De Stefani, D., et al. 2011. Nature. 476: 336-40. PMID: 21685888
9. Molecular nature and physiological role of the mitochondrial calcium uniporter channel.  |  Alevriadou, BR., et al. 2021. Am J Physiol Cell Physiol. 320: C465-C482. PMID: 33296287
10. The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis.  |  Xue, K., et al. 2022. Cell Metab. 34: 1325-1341.e6. PMID: 35977541
11. Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis.  |  Marmolejo-Garza, A., et al. 2023. Cell Death Dis. 14: 772. PMID: 38007529
12. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.  |  Jabs, EW., et al. 1994. Nat Genet. 8: 275-9. PMID: 7874170

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CCDC109A Antibody (E-9) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-CCDC109A Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CCDC109A Antibody (E-9) Specifications

Alternate Product Name: MCU

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 110-129

Epitope Target: CCDC109A

Epitope Species: human

Product Reactivity/Detection: CCDC109A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for CCDC109A Antibody (E-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin