Uteroglobin/SCGB1A1/CC10 Antibody (E-11): sc-365992

CC10 Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects CC10 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CC10 (E-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Clara cell 10 (CC10), also known as secretoglobin family 1A member 1, functions as a phospholipase A2 inhibitor, which is crucial for regulating inflammatory responses in the lungs. By inhibiting phospholipase A2, CC10 plays a significant role in modulating inflammatory mediator production, thereby contributing to airway homeostasis maintenance and potentially influencing conditions such as asthma. CC10 is expressed in nonciliated airway epithelial cells and is regulated by various transcription factors, including AP-1 and hepatocyte nuclear factor-3, with expression levels fluctuating in relation to the ovarian menstrual cycle and being influenced by progesterone in the human endometrium. Notably, CC10 overexpression in the non-small cell lung cancer cell line A549 has been associated with a marked reduction in matrix metalloproteinases MMP-2 and MMP-9, suggesting that CC10 loss may facilitate carcinogenesis by enhancing invasive properties of cancer cells.

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Uteroglobin/SCGB1A1/CC10 Antibody (E-11) References:

1. Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions.  |  Bernard, A., et al. 1992. Clin Chim Acta. 207: 239-49. PMID: 1395029
2. The influence of gestation and mechanical ventilation on serum clara cell secretory protein (CC10) concentrations in ventilated and nonventilated newborn infants.  |  Loughran-Fowlds, A., et al. 2006. Pediatr Res. 60: 103-8. PMID: 16690962
3. The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial.  |  Chen, J., et al. 2007. Cancer Epidemiol Biomarkers Prev. 16: 577-83. PMID: 17372255
4. Higher levels of the anti-inflammatory protein CC10 are associated with improvement in bronchial dysplasia and sputum cytometric assessment in individuals at high risk for lung cancer.  |  Chen, J., et al. 2008. Clin Cancer Res. 14: 1590-7. PMID: 18316584
5. CC10 mRNA and protein expression in Clara cells of CD-1 mice following exposure to styrene or its metabolites styrene oxide or 4-vinylphenol.  |  Harvilchuck, JA., et al. 2008. Toxicol Lett. 183: 28-35. PMID: 18926891
6. Tissue-specific expression, hormonal regulation and 5'-flanking gene region of the rat Clara cell 10 kDa protein: comparison to rabbit uteroglobin.  |  Hagen, G., et al. 1990. Nucleic Acids Res. 18: 2939-46. PMID: 2349092
7. Clara cell 10 kDa protein (CC10): comparison of structure and function to uteroglobin.  |  Singh, G., et al. 1990. Biochim Biophys Acta. 1039: 348-55. PMID: 2378892
8. Expression of Clara cell 10-kD gene in the human endometrium and its relationship to ovarian menstrual cycle.  |  Peri, A., et al. 1994. DNA Cell Biol. 13: 495-503. PMID: 7517678
9. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease.  |  Hay, JG., et al. 1995. Am J Physiol. 268: L565-75. PMID: 7733299
10. The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families.  |  Sawaya, PL., et al. 1993. Mol Cell Biol. 13: 3860-71. PMID: 8321193
11. Serum and BAL Clara cell 10 kDa protein (CC10) levels and CC10-positive bronchiolar cells are decreased in smokers.  |  Shijubo, N., et al. 1997. Eur Respir J. 10: 1108-14. PMID: 9163654
12. Overexpression of CC10 modifies neoplastic potential in lung cancer cells.  |  Szabo, E., et al. 1998. Cell Growth Differ. 9: 475-85. PMID: 9663466

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Uteroglobin/SCGB1A1/CC10 Antibody (E-11) has 84 citations in a variety of scientific publications.

Primary antibodies like Anti-Uteroglobin/SCGB1A1/CC10 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Uteroglobin/SCGB1A1/CC10 Antibody (E-11) Specifications

Alternate Product Name: SCGB1A1

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 17-91

Epitope Target: CC10

Epitope Species: human

Product Reactivity/Detection: CC10

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 84 citations in various scientific publications

Available Conjugates/Forms for Uteroglobin/SCGB1A1/CC10 Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin