CBS Antibody (A-3): sc-515180
- CBS Antibody (A-3) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 137-154 near the N-terminus of CBS of human origin
- recommended for detection of CBS of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See CBS (B-4): sc-133154 for CBS antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for CBS Antibody (A-3) for WB and IHC(P) applications. This reagent is now offered in a bundle with CBS Antibody (A-3) (see ordering information below).
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SEE ALSO...
CBS Antibody (A-3) is a mouse monoclonal IgG3 antibody that detects cystathionine β-synthase (CBS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CBS is a crucial cytoplasmic protein predominantly expressed in the human liver and pancreas, with lower levels found in the heart and brain, and plays a vital role in the first step of homocysteine transulfuration. This enzyme catalyzes the conversion of homocysteine, a potentially harmful amino acid, into cystathionine, utilizing pyridoxal phosphate as a cofactor. The regulation of CBS activity is significantly influenced by allosteric activation from adenosyl-methionine, which ensures optimal function under varying physiological conditions. Deficiencies in CBS can lead to homocystinuria, a genetic disorder characterized by homocysteine accumulation that can result in severe health issues, including arteriosclerosis, thrombosis, dislocated optic lenses, cognitive impairments, and skeletal abnormalities. CBS (A-3) antibody serves as an essential tool for researchers studying CBS implications in metabolic disorders and potential therapeutic targets.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CBS Antibody (A-3) | sc-515180 | 200 µg/ml | $322.00 | |||
CBS Antibody (A-3): m-IgG3 BP-HRP Bundle | sc-550529 | 200 µg Ab; 40 µg BP | $361.00 | |||
CBS (A-3) Neutralizing Peptide | sc-515180 P | 100 µg/0.5 ml | $69.00 |