CBLL1 Antibody (3B12): sc-517157

CBLL1 Antibody (3B12) is a mouse monoclonal IgG2a kappa light chain antibody that detects CBLL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CBLL1 antibody (3B12) is available as a non-conjugated format. CBLL1, also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1, HAKAI, or RING finger protein 188, is a 491 amino acid protein characterized by the presence of one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 functions as an E3 ubiquitin-protein ligase, facilitating the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to target proteins for degradation. Upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, leading to the endocytosis of the E-cadherin complex and the disruption of epithelial cell-cell contacts. This regulatory function of CBLL1 on E-cadherin is vital for maintaining cell adhesion and may also influence the processes of epithelial-mesenchymal transition, which are critical in development and cancer progression.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CBLL1 Antibody (3B12) References:

1. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.  |  Fujita, Y., et al. 2002. Nat Cell Biol. 4: 222-31. PMID: 11836526
2. E-cadherin and Hakai: signalling, remodeling or destruction?  |  Pece, S. and Gutkind, JS. 2002. Nat Cell Biol. 4: E72-4. PMID: 11944035
3. Newest findings on the oldest oncogene; how activated src does it.  |  Frame, MC. 2004. J Cell Sci. 117: 989-98. PMID: 14996930
4. The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells.  |  Carter, O., et al. 2004. J Nutr. 134: 3441S-3444S. PMID: 15570051
5. Microarray profiling of genes differentially expressed during erythroid differentiation of murine erythroleukemia cells.  |  Heo, HS., et al. 2005. Mol Cells. 20: 57-68. PMID: 16258242
6. Evolutionary insights into the unique electromotility motor of mammalian outer hair cells.  |  Okoruwa, OE., et al. 2008. Evol Dev. 10: 300-15. PMID: 18460092

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CBLL1 Antibody (3B12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CBLL1 Antibody (3B12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CBLL1 Antibody (3B12) Specifications

Alternate Product Name: CBLL1

Product Clone Name: 3B12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-100

Epitope Target: CBLL1

Epitope Species: human

Product Reactivity/Detection: CBLL1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CBLL1 Antibody (3B12): N/A