CB1/Cannabinoid Receptor 1/CNR1 Antibody (C-11): sc-518035

CB1 Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects CB1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CB1 antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CB1, a member of the G-protein coupled receptor family, plays a crucial role in mediating the effects of psychoactive cannabinoids by inhibiting adenylate cyclase activity, which is vital for regulating neurotransmitter release and neuronal excitability. Predominantly expressed in the brain, CB1 is also found in lower levels in the testis, highlighting CB1′s significance in central nervous system functions such as pain perception, motor control, memory, and neuroendocrine regulation. Notably, phosphorylation of CB1 at serine 316 has been shown to disrupt CB1′s inhibitory effects on calcium channels while activating potassium currents, indicating a complex regulatory mechanism that may influence various brain functions and potentially contribute to the addictive behaviors associated with substances like THC found in marijuana. CB1 (C-11) antibody′s ability to effectively detect and characterize CB1 makes CB1 (C-11) antibody an invaluable tool for researchers studying cannabinoid signaling pathways and their implications in both physiological and pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CB1/Cannabinoid Receptor 1/CNR1 Antibody (C-11) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-CB1/Cannabinoid Receptor 1/CNR1 Antibody (C-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CB1/Cannabinoid Receptor 1/CNR1 Antibody (C-11) Specifications

Alternate Product Name: CB1

Product Clone Name: C-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-150

Epitope Target: CB1

Epitope Species: human

Product Reactivity/Detection: CB1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for CB1/Cannabinoid Receptor 1/CNR1 Antibody (C-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CB1/Cannabinoid Receptor 1/CNR1 antibody is CB1/Cannabinoid Receptor 1/CNR1 Antibody (2F9): sc-293419.