cathepsin Z Antibody (F-6): sc-376976

cathepsin Z Antibody (F-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects cathepsin Z of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-cathepsin Z antibody (F-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cathepsin Z, also known as cathepsin X or P, is a cysteine protease that exhibits both carboxy-dipeptidase and carboxy-monopeptidase activities, playing a crucial role in normal intracellular protein degradation. Cathepsin Z is widely expressed across various tissues, and cathepsin Z involvement in tumor progression highlights its significance in cancer biology. Anti-cathepsin Z antibody (F-6) participates in the degradation of extracellular matrix components and modulates cellular signaling pathways, underscoring its importance in maintaining cellular homeostasis and influencing pathological processes. Understanding cathepsin Z function is essential for elucidating its potential as a therapeutic target in diseases characterized by dysregulated proteolytic activity.

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cathepsin Z Antibody (F-6) References:

1. Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.  |  Guncar, G., et al. 2000. Structure. 8: 305-13. PMID: 10745011
2. Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.  |  Deussing, J., et al. 2000. Biochim Biophys Acta. 1491: 93-106. PMID: 10760573
3. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.  |  Shi, GP., et al. 1992. J Biol Chem. 267: 7258-62. PMID: 1373132
4. Molecular organization of the human cathepsin D gene.  |  Redecker, B., et al. 1991. DNA Cell Biol. 10: 423-31. PMID: 2069717
5. Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family.  |  Pungerčar, J. and Ivanovski, G. 2000. Pflugers Arch. 439: r116-r118. PMID: 28176093
6. Tissue expression and immunolocalization of a novel human cathepsin P.  |  Pungerčar, J., et al. 2000. Pflugers Arch. 439: r119-r121. PMID: 28176094
7. Molecular cloning and sequencing of cDNA for rat cathepsin L.  |  Ishidoh, K., et al. 1987. FEBS Lett. 223: 69-73. PMID: 3666143
8. Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases.  |  Ishidoh, K., et al. 1987. FEBS Lett. 226: 33-7. PMID: 3691815
9. Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.  |  Heusel, JW., et al. 1993. Blood. 81: 1614-23. PMID: 8453108
10. Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development.  |  Rantakokko, J., et al. 1996. FEBS Lett. 393: 307-13. PMID: 8814310
11. Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location.  |  Santamaría, I., et al. 1998. J Biol Chem. 273: 16816-23. PMID: 9642240
12. Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions.  |  Nägler, DK. and Ménard, R. 1998. FEBS Lett. 434: 135-9. PMID: 9738465

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cathepsin Z Antibody (F-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-cathepsin Z Antibody (F-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cathepsin Z Antibody (F-6) Specifications

Alternate Product Name: CTSZ

Product Clone Name: F-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 277-303

Epitope Target: cathepsin Z

Epitope Species: human

Product Reactivity/Detection: cathepsin Z

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for cathepsin Z Antibody (F-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin