cathepsin O Antibody (E-7): sc-390117
- cathepsin O Antibody (E-7) is a mouse monoclonal IgG2a κ cathepsin O antibody provided at 200 µg/ml
- raised against amino acids 13-321 mapping at the C-terminus of cathepsin O of human origin
- cathepsin O Antibody (E-7) is recommended for detection of cathepsin O of human origin by WB, IP, IF and ELISA
- Anti-cathepsin O Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for cathepsin O Antibody (E-7) for WB applications. These reagents are now offered in bundles with cathepsin O Antibody (E-7) (see ordering information below).
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Cathepsin O Antibody (E-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects cathepsin O protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cathepsin O antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cathepsin O, also known as CTSO, is a member of the cysteine protease class within the cathepsin family, which plays a crucial role in cellular metabolism by participating in peptide biosynthesis and protein degradation. This endoproteinase is particularly important for extracellular matrix remodeling, which is vital for processes such as tissue repair and development. Cathepsin O is predominantly expressed in the ovary, kidney, and placenta, with lower expression levels in the thymus and skeletal muscle, highlighting its significance in reproductive and renal physiology. Cathepsin O maintains essential structural features characteristic of cysteine proteinases, including an active site cysteine residue that facilitates covalent intermediate formation during peptide hydrolysis, underscoring its enzymatic function in proteolytic activity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cathepsin O Antibody (E-7) References:
- Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. | Shi, GP., et al. 1992. J Biol Chem. 267: 7258-62. PMID: 1373132
- Molecular organization of the human cathepsin D gene. | Redecker, B., et al. 1991. DNA Cell Biol. 10: 423-31. PMID: 2069717
- Molecular cloning and sequencing of cDNA for rat cathepsin L. | Ishidoh, K., et al. 1987. FEBS Lett. 223: 69-73. PMID: 3666143
- Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases. | Ishidoh, K., et al. 1987. FEBS Lett. 226: 33-7. PMID: 3691815
- Isolation and sequencing of two cDNA clones encoding rat spleen cathepsin E and analysis of the activation of purified procathepsin E. | Okamoto, K., et al. 1995. Arch Biochem Biophys. 322: 103-11. PMID: 7574663
- Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. | Shi, GP., et al. 1995. FEBS Lett. 357: 129-34. PMID: 7805878
- Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues. | Velasco, G., et al. 1994. J Biol Chem. 269: 27136-42. PMID: 7929457
- Cathepsin B, a cysteine protease implicated in metastatic progression, is also expressed during regression of the rat prostate and mammary glands. | Guenette, RS., et al. 1994. Eur J Biochem. 226: 311-21. PMID: 8001549
- Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene. | Heusel, JW., et al. 1993. Blood. 81: 1614-23. PMID: 8453108
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cathepsin O Antibody (E-7) | sc-390117 | 200 µg/ml | $316.00 | |||
cathepsin O Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-526123 | 200 µg Ab; 10 µg BP | $354.00 | |||
cathepsin O Antibody (E-7): m-IgG2a BP-HRP Bundle | sc-546507 | 200 µg Ab; 10 µg BP | $354.00 | |||
cathepsin O Antibody (E-7) AC | sc-390117 AC | 500 µg/ml, 25% agarose | $416.00 | |||
cathepsin O Antibody (E-7) HRP | sc-390117 HRP | 200 µg/ml | $316.00 | |||
cathepsin O Antibody (E-7) FITC | sc-390117 FITC | 200 µg/ml | $330.00 | |||
cathepsin O Antibody (E-7) PE | sc-390117 PE | 200 µg/ml | $343.00 | |||
cathepsin O Antibody (E-7) Alexa Fluor® 488 | sc-390117 AF488 | 200 µg/ml | $357.00 | |||
cathepsin O Antibody (E-7) Alexa Fluor® 546 | sc-390117 AF546 | 200 µg/ml | $357.00 | |||
cathepsin O Antibody (E-7) Alexa Fluor® 594 | sc-390117 AF594 | 200 µg/ml | $357.00 | |||
cathepsin O Antibody (E-7) Alexa Fluor® 647 | sc-390117 AF647 | 200 µg/ml | $357.00 | |||
cathepsin O Antibody (E-7) Alexa Fluor® 680 | sc-390117 AF680 | 200 µg/ml | $357.00 | |||
cathepsin O Antibody (E-7) Alexa Fluor® 790 | sc-390117 AF790 | 200 µg/ml | $357.00 |