cathepsin L Antibody (G-11): sc-390367

cathepsin L Antibody (G-11) is a mouse monoclonal IgG2a kappa light chain antibody designed to recognize an epitope mapping between amino acids 263-291 at the C-terminus of cathepsin L, also known as CTSL, major excreted protein (MEP), or CATL. anti-cathepsin L antibody (G-11) demonstrates strong reactivity with cathepsin L from both mouse and rat species, making it ideal for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cathepsin L is a lysosomal cysteine protease that plays a crucial role in the intracellular degradation of proteins including collagen, elastin, and α-1 protease inhibitor, which is essential for maintaining cellular metabolism and homeostasis. Structurally, cathepsin L functions as a dimer composed of disulfide-linked heavy and light chains derived from a single precursor protein, a configuration that is vital for enzymatic activity and stability. Post-translational modifications of cathepsin L, such as glycosylation and proteolytic processing from procathepsin L to its active form, are critical for proper localization within the lysosome and regulation under acidic conditions. These modifications ensure optimal activity in the lysosomal environment while preventing unwanted protease activity in other cellular compartments. By targeting the specific C-terminal epitope, cathepsin L monoclonal antibody (G-11) enables precise detection and analysis of expression, processing, and functional dynamics in various biological studies. For investigating protein degradation pathways, exploring cellular metabolism, or examining the role of proteases in disease mechanisms, cathepsin L (G-11) antibody provides the specificity and reliability needed to advance research and scientific discoveries.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cathepsin L Antibody (G-11) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-cathepsin L Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cathepsin L Antibody (G-11) Specifications

Alternate Product Name: CTSL

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 263-291

Epitope Target: cathepsin L

Epitope Species: mouse

Product Reactivity/Detection: cathepsin L

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for cathepsin L Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred cathepsin L antibody is cathepsin L Antibody (33/2): sc-32320.