cathepsin L Antibody (CPLH-2D4): sc-32801

Cathepsin L Antibody (CPLH-2D4) is a mouse monoclonal IgG1 kappa light chain antibody engineered to recognize native human procathepsin L, also known as CTSL, major excreted protein (MEP), or CATL. Anti-cathepsin L antibody (CPLH-2D4) exhibits strong reactivity with procathepsin L of human origin, making it an invaluable tool for applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cathepsin L is a lysosomal cysteine protease that plays a pivotal role in intracellular protein degradation, including the breakdown of collagen, elastin, and α-1 protease inhibitor, which is essential for maintaining cellular homeostasis and facilitating processes like tissue remodeling and immune responses. Structurally, cathepsin L functions as a dimer composed of disulfide-linked heavy and light chains, derived from a single protein precursor, a configuration that is crucial for enzymatic activity and stability. This dimeric structure ensures effective protein catabolism and regulation within the lysosome, highlighting the importance of accurately detecting and studying cathepsin L. By targeting the native form of procathepsin L, cathepsin L (CPLH-2D4) antibody allows researchers to investigate expression, processing, and functional dynamics in various biological contexts. Anti-cathepsin L antibody (CPLH-2D4) is recommended for researchers exploring protein degradation pathways, cellular metabolism, or the role of proteases in disease mechanisms.

The preferred cathepsin L antibody is cathepsin L Antibody (33/2): sc-32320.