cathepsin A Antibody (4526): sc-73766

Cathepsin A Antibody (4526) is a mouse monoclonal IgG2a kappa light chain antibody that detects human cathepsin A by western blotting (WB) and immunoprecipitation (IP). Anti-cathepsin A antibody (4526) is available as a non-conjugated format. Cathepsin A, a serine carboxypeptidase, plays a crucial role in lysosomal function by forming a high molecular weight complex with β-galactosidase and α-neuraminidase, thereby protecting these enzymes from degradation within the lysosome. This protective mechanism is vital for maintaining cellular metabolism and ensuring proper peptide biosynthesis and protein degradation. Deficiencies in cathepsin A can lead to a cascade of issues, including the dysfunction of β-galactosidase and α-neuraminidase, which are essential for the breakdown of glycoproteins and glycolipids. The gene encoding human cathepsin A is located on chromosome 20q13.12, and mutations in this gene are associated with galactosialidosis, a lysosomal storage disorder characterized by the accumulation of undegraded substrates due to the deficiencies of these critical enzymes. Cathepsin A monoclonal antibody (4526) specifically targets this protein, making anti-cathepsin A antibody (4526) an invaluable tool for researchers studying lysosomal function and related disorders.

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cathepsin A Antibody (4526) References:

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