catalase Antibody (H-9): sc-271803

Catalase Antibody (H-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects catalase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-catalase antibody (H-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Catalase is a crucial enzyme located primarily in peroxisomes, where catalase plays a vital role in the detoxification of hydrogen peroxide, a harmful byproduct of cellular metabolism. By converting hydrogen peroxide into water and oxygen, catalase helps maintain cellular homeostasis and protects cells from oxidative damage, which is particularly important in preventing cellular aging and the development of various diseases, including cancer and neurodegenerative disorders. Defects in the gene encoding catalase can lead to acatalasia, a rare condition characterized by the absence of catalase activity in red blood cells, resulting in severe oral lesions and increased susceptibility to oxidative stress. The ability of catalase to form a homotetramer enhances catalase stability and efficiency, making catalase an essential component of the cellular antioxidant defense system.

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catalase Antibody (H-9) References:

1. The Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men.  |  Rosmond, R., et al. 2003. Diabetes Metab Res Rev. 19: 159-63. PMID: 12673785
2. Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/bgene polymorphisms are associated with essential hypertension.  |  Rodríguez-Esparragón, FJ., et al. 2003. J Hypertens. 21: 1649-55. PMID: 12923396
3. Catalase and PPARgamma2 genotype and risk of systemic lupus erythematosus in Koreans.  |  Eny, KM., et al. 2005. Lupus. 14: 351-5. PMID: 15934434
4. 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats.  |  Zhao, X., et al. 2006. J Cereb Blood Flow Metab. 26: 811-20. PMID: 16208315
5. Peroxisomes and aging.  |  Terlecky, SR., et al. 2006. Biochim Biophys Acta. 1763: 1749-54. PMID: 17027095
6. The role of catalase in pulmonary fibrosis.  |  Odajima, N., et al. 2010. Respir Res. 11: 183. PMID: 21190578
7. Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis.  |  Hackenberg, T., et al. 2013. Plant Cell. 25: 4616-26. PMID: 24285797
8. Oxidative Stress and Catalase Gene.  |  Ershova, OA., et al. 2016. Bull Exp Biol Med. 161: 400-3. PMID: 27496033
9. Oxime-functionalized cryogel disks for catalase immobilization.  |  Inanan, T., et al. 2018. Int J Biol Macromol. 114: 812-820. PMID: 29626600
10. Ecofriendly approaches to efficiently enhance catalase performance.  |  Leonida, MD., et al. 2024. Int J Biol Macromol. 280: 135597. PMID: 39278428
11. Pseudo infantile Refsum's disease: catalase-deficient peroxisomal particles with partial deficiency of plasmalogen synthesis and oxidation of fatty acids.  |  Aubourg, P., et al. 1993. Pediatr Res. 34: 270-6. PMID: 7510868
12. Catalase and PPARgamma2 genotype and risk of rheumatoid arthritis in Koreans.  |  El-Sohemy, A., et al. 2006. Rheumatol Int. 26: 388-92. PMID: 15988600

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-catalase Antibody (H-9) has 122 citations in a variety of scientific publications.

Primary antibodies like Anti-catalase Antibody (H-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

catalase Antibody (H-9) Specifications

Alternate Product Name: catalase

Product Clone Name: H-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 471-503

Epitope Target: catalase

Epitope Species: mouse

Product Reactivity/Detection: catalase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 122 citations in various scientific publications

Available Conjugates/Forms for catalase Antibody (H-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin