catalase Antibody (A-7): sc-271242
- catalase Antibody (A-7) is a mouse monoclonal IgG2b κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 415-453 within an internal region of catalase of human origin
- recommended for detection of catalase of human origin by WB, IP, IF, IHC(P) and ELISA
- See catalase (H-9): sc-271803 for catalase antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for catalase Antibody (A-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with catalase Antibody (A-7) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Catalase (A-7) is a IgG2b antibody that detects catalase in human samples through applications such as western blotting (WB), immunoprecipitation (IP), protease activity assays, and enzyme-linked immunosorbent assay (ELISA). Catalase monoclonal antibody (A-7) recognizes a crucial enzyme that plays a vital role in cellular defense against oxidative stress by catalyzing the decomposition of hydrogen peroxide into water and oxygen, thereby preventing potential cellular damage. Anti-catalase antibody (A-7) targets a protein predominantly located in peroxisomes, organelles responsible for lipid metabolism and the detoxification of harmful byproducts of cellular metabolism. Catalase (A-7) antibody identifies a homotetramer, which is essential for enzymatic activity, and defects in the gene encoding catalase can lead to acatalasia, a condition characterized by the absence of catalase activity and associated with severe oral lesions. Anti-catalase antibody (A-7) serves as an invaluable tool for researchers studying oxidative damage and related pathologies, particularly in conditions where an imbalance in hydrogen peroxide levels leads to oxidative stress, such as rheumatoid arthritis and neurodegenerative disorders.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
catalase Antibody (A-7) References:
- Mechanisms of catalase activity of heme peroxidases. | Vlasits, J., et al. 2010. Arch Biochem Biophys. 500: 74-81. PMID: 20434429
- Mechanisms of oxidant generation by catalase. | Heck, DE., et al. 2010. Ann N Y Acad Sci. 1203: 120-5. PMID: 20716293
- Catalase deletion promotes prediabetic phenotype in mice. | Heit, C., et al. 2017. Free Radic Biol Med. 103: 48-56. PMID: 27939935
- BAK regulates catalase release from peroxisomes. | Fujiki, Y., et al. 2017. Mol Cell Oncol. 4: e1306610. PMID: 28616584
- Catalase inhibition induces pexophagy through ROS accumulation. | Lee, JN., et al. 2018. Biochem Biophys Res Commun. 501: 696-702. PMID: 29753736
- Catalase is required for peroxisome maintenance during adipogenesis. | Nitta, Y., et al. 2020. Biochim Biophys Acta Mol Cell Biol Lipids. 1865: 158726. PMID: 32335291
- Catalase Overexpression Drives an Aggressive Phenotype in Glioblastoma. | Flor, S., et al. 2021. Antioxidants (Basel). 10: PMID: 34943091
- Stable Dried Catalase Particles Prepared by Electrospraying. | Schlosser, CS., et al. 2022. Nanomaterials (Basel). 12: PMID: 35889708
- β-sitosterol alleviates atherosclerosis by regulating catalase. | Jiang, S., et al. 2024. Heliyon. 10: e35639. PMID: 39165938
- Superoxide radical inhibits catalase. | Kono, Y. and Fridovich, I. 1982. J Biol Chem. 257: 5751-4. PMID: 6279612
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
catalase Antibody (A-7) | sc-271242 | 200 µg/ml | $316.00 | |||
catalase Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-534905 | 200 µg Ab; 40 µg BP | $354.00 | |||
catalase (A-7) Neutralizing Peptide | sc-271242 P | 100 µg/0.5 ml | $68.00 |