casein kinase IIα Antibody (D-10): sc-365762

casein kinase IIα Antibody (D-10) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect casein kinase IIα (CK2α), also known as CSNK2A1, across multiple species including mouse, rat, and human. anti-CK2α antibody (D-10) is raised against amino acids 1-320 of human CK2α, ensuring strong reactivity with both CK2α and its isoform CK2α′ (CSNK2A2) in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CK2α is a catalytic subunit of the casein kinase II (CK2) enzyme, which typically assembles into a tetrameric structure composed of two catalytic α or α′ subunits and two regulatory β subunits. This quaternary structure is essential for the enzyme′s stability and its ability to phosphorylate a diverse range of substrates, thereby regulating critical cellular processes including cell cycle progression, DNA replication and repair, apoptosis, and transcriptional regulation. The structural configuration of CK2α within the CK2 complex is vital for maintaining cellular homeostasis and has significant implications in various diseases, particularly cancer, where dysregulation of CK2α contributes to tumorigenesis and uncontrolled cell proliferation. By facilitating the formation of the active tetrameric complex, CK2α ensures precise modulation of signaling pathways that are crucial for cell growth and survival. CK2α monoclonal antibody (D-10) provides researchers with a reliable tool to investigate the structural and functional roles of CK2α in both normal physiological and pathological contexts, supporting advancements in the understanding of cellular biology and disease mechanisms.

The preferred casein kinase IIα antibody is casein kinase IIα Antibody (1AD9): sc-12738.