casein kinase Iδ Antibody (C-4): sc-514942

casein kinase Iδ Antibody (C-4) is a mouse monoclonal IgG3 antibody that detects casein kinase Iδ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Casein kinase Iδ is a vital member of the casein kinase I family, which plays a crucial role in various cellular processes, including the regulation of circadian rhythms, cell division, and apoptosis. Casein kinase Iδ is primarily located in the cytoplasm and nucleus, where casein kinase Iδ participates in signaling pathways that influence gene expression and cellular responses to stress. The localization of casein kinase Iδ is significant because this positioning allows for precise modulation of substrates, which include key proteins involved in cell cycle regulation and DNA repair mechanisms. By phosphorylating these substrates, casein kinase Iδ can alter their activity, stability, and interactions, thereby impacting critical cellular functions. The ability of casein kinase Iδ to influence such diverse processes underscores casein kinase Iδ′s importance in maintaining cellular homeostasis and potential implications in various diseases, including cancer and neurodegenerative disorders. Anti-casein kinase Iδ antibody (C-4) is an essential tool for researchers aiming to explore the intricate roles of this protein in health and disease.

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casein kinase Iδ Antibody (C-4) References:

1. Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.  |  Camacho, F., et al. 2001. FEBS Lett. 489: 159-65. PMID: 11165242
2. Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology.  |  Maritzen, T., et al. 2003. Eur J Cell Biol. 82: 369-78. PMID: 12924632
3. Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.  |  Tsai, IC., et al. 2007. Int J Cancer. 120: 1005-12. PMID: 17131344
4. Dpr Acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon.  |  Teran, E., et al. 2009. PLoS One. 4: e5522. PMID: 19440376
5. Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.  |  Lee, H., et al. 2009. Proc Natl Acad Sci U S A. 106: 21359-64. PMID: 19948962
6. Casein kinase I delta controls centrosome positioning during T cell activation.  |  Zyss, D., et al. 2011. J Cell Biol. 195: 781-97. PMID: 22123863
7. Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.  |  Huang, Y., et al. 2014. PLoS Genet. 10: e1004536. PMID: 25211129
8. Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta.  |  Graves, PR. and Roach, PJ. 1995. J Biol Chem. 270: 21689-94. PMID: 7665585
9. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.  |  Rivers, A., et al. 1998. J Biol Chem. 273: 15980-4. PMID: 9632646
10. Crystallographic studies of casein kinase I delta toward a structural understanding of auto-inhibition.  |  Longenecker, KL., et al. 1998. Acta Crystallogr D Biol Crystallogr. 54: 473-5. PMID: 9761932

The preferred casein kinase Iδ antibody is casein kinase Iδ Antibody (C-8): sc-55553.