Carbonyl reductase 3 Antibody (E-12): sc-374393
- Carbonyl reductase 3 Antibody (E-12) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 126-176 mapping within an internal region of Carbonyl reductase 3 of human origin
- Carbonyl reductase 3 Antibody (E-12) is recommended for detection of Carbonyl reductase 3 of human origin by WB, IP, IF and ELISA
- Anti-Carbonyl reductase 3 Antibody (E-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Carbonyl reductase 3 Antibody (E-12) for WB applications. These reagents are now offered in bundles with Carbonyl reductase 3 Antibody (E-12) (see ordering information below).
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Carbonyl reductase 3 Antibody (E-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Carbonyl reductase 3 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Carbonyl reductase 3 antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Carbonyl reductase 3 plays a crucial role in cellular metabolism by catalyzing the NADPH-dependent reduction of carbonyl compounds, which are often products of lipid peroxidation, to corresponding alcohols. This enzymatic activity maintains cellular homeostasis and detoxifies harmful metabolites, influencing various physiological processes. Carbonyl reductase 3 interacts with other proteins involved in metabolic pathways, including Carbonyl reductase 1, sharing significant sequence similarity and functional overlap. Genetic variations in genes encoding these reductases can lead to differences in drug metabolism among individuals, highlighting Carbonyl reductase 3′s importance in pharmacogenomics and potential implications in cancer and diabetes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Carbonyl reductase 3 Antibody (E-12) References:
- Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1. | Olson, LE., et al. 2003. Cancer Res. 63: 6602-6. PMID: 14583452
- Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3). | Lakhman, SS., et al. 2005. Drug Metab Dispos. 33: 254-7. PMID: 15537833
- Fine mapping of a region on chromosome 21q21.11-q22.3 showing linkage to type 1 diabetes. | Bergholdt, R., et al. 2005. J Med Genet. 42: 17-25. PMID: 15635070
- An unbiased cell morphology-based screen for new, biologically active small molecules. | Tanaka, M., et al. 2005. PLoS Biol. 3: e128. PMID: 15799708
- Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology. | Oppermann, U. 2007. Annu Rev Pharmacol Toxicol. 47: 293-322. PMID: 17009925
- A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. | Gonzalez-Covarrubias, V., et al. 2007. Drug Metab Dispos. 35: 973-80. PMID: 17344335
- Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor. | Lakhman, SS., et al. 2007. Mol Pharmacol. 72: 734-43. PMID: 17569794
- Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. | Watanabe, K., et al. 1998. Genomics. 52: 95-100. PMID: 9740676
- Cloning and bacterial expression of monomeric short-chain dehydrogenase/reductase (carbonyl reductase) from CHO-K1 cells. | Terada, T., et al. 2000. Eur J Biochem. 267: 6849-57. PMID: 11082196
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Carbonyl reductase 3 Antibody (E-12) | sc-374393 | 200 µg/ml | $322.00 | |||
Carbonyl reductase 3 Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-529733 | 200 µg Ab; 10 µg BP | $361.00 | |||
Carbonyl reductase 3 Antibody (E-12): m-IgGκ BP-HRP Bundle | sc-522719 | 200 µg Ab, 40 µg BP | $361.00 | |||
Carbonyl reductase 3 Antibody (E-12): m-IgG1 BP-HRP Bundle | sc-543659 | 200 µg Ab; 20 µg BP | $361.00 | |||
Carbonyl reductase 3 Antibody (E-12) AC | sc-374393 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Carbonyl reductase 3 Antibody (E-12) HRP | sc-374393 HRP | 200 µg/ml | $322.00 | |||
Carbonyl reductase 3 Antibody (E-12) FITC | sc-374393 FITC | 200 µg/ml | $336.00 | |||
Carbonyl reductase 3 Antibody (E-12) PE | sc-374393 PE | 200 µg/ml | $349.00 | |||
Carbonyl reductase 3 Antibody (E-12) Alexa Fluor® 488 | sc-374393 AF488 | 200 µg/ml | $364.00 | |||
Carbonyl reductase 3 Antibody (E-12) Alexa Fluor® 546 | sc-374393 AF546 | 200 µg/ml | $364.00 | |||
Carbonyl reductase 3 Antibody (E-12) Alexa Fluor® 594 | sc-374393 AF594 | 200 µg/ml | $364.00 | |||
Carbonyl reductase 3 Antibody (E-12) Alexa Fluor® 647 | sc-374393 AF647 | 200 µg/ml | $364.00 | |||
Carbonyl reductase 3 Antibody (E-12) Alexa Fluor® 680 | sc-374393 AF680 | 200 µg/ml | $364.00 | |||
Carbonyl reductase 3 Antibody (E-12) Alexa Fluor® 790 | sc-374393 AF790 | 200 µg/ml | $364.00 |