CapZ-β Antibody (52): sc-136502
- CapZ-β Antibody (52) is a mouse monoclonal IgG1 κ CapZ-β antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 162-267 of CapZ-β of human origin
- recommended for detection of CapZ-β isoforms 1 and 2 of mouse, rat, human, canine and avian origin by WB and IP
- available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CapZ-β Antibody (52) for WB applications. These reagents are now offered in bundles with CapZ-β Antibody (52) (see ordering information below).
CapZ-β Antibody (52) is a mouse monoclonal IgG1 kappa light chain antibody that detects CapZ-beta protein in mouse, rat, human, canine, and avian species by western blotting (WB) and immunoprecipitation (IP). Anti-CapZ-β antibody (52) is available in non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). CapZ-β protein, also known as capping protein (Actin filament) muscle Z-line, beta, plays a crucial role in regulating actin dynamics within cells. CapZ-β protein forms a heterodimeric complex with α subunits, which caps barbed ends of actin filaments, preventing addition or loss of actin monomers. This regulation maintains cytoskeletal structural integrity and facilitates cellular processes like motility, division, and intracellular transport. Through control of actin filament growth, CapZ-β protein enables cells to respond to mechanical and biochemical signals, making CapZ-β protein essential for muscle contraction and other actin-dependent functions.
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CapZ-β Antibody (52) References:
- Crystal structure of CapZ: structural basis for actin filament barbed end capping. | Yamashita, A., et al. 2003. EMBO J. 22: 1529-38. PMID: 12660160
- Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. | Hutchings, NJ., et al. 2003. J Biol Chem. 278: 22396-403. PMID: 12690097
- F-actin capping (CapZ) and other contractile saphenous vein smooth muscle proteins are altered by hemodynamic stress: a proteonomic approach. | McGregor, E., et al. 2004. Mol Cell Proteomics. 3: 115-24. PMID: 14612593
- Porcine muscle sensory attributes associate with major changes in gene networks involving CAPZB, ANKRD1, and CTBP2. | Ponsuksili, S., et al. 2009. Funct Integr Genomics. 9: 455-71. PMID: 19597856
- Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. | Barron-Casella, EA., et al. 1995. J Biol Chem. 270: 21472-9. PMID: 7665558
- Interaction of S100a0 protein with the actin capping protein, CapZ: characterization of a putative S100a0 binding site in CapZ alpha-subunit. | Ivanenkov, VV., et al. 1996. Biochem Biophys Res Commun. 221: 46-50. PMID: 8660341
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CapZ-β Antibody (52) | sc-136502 | 200 µg/ml | $322.00 | |||
CapZ-β Antibody (52): m-IgG Fc BP-HRP Bundle | sc-528829 | 200 µg Ab; 10 µg BP | $361.00 | |||
CapZ-β Antibody (52): m-IgGκ BP-HRP Bundle | sc-521376 | 200 µg Ab, 40 µg BP | $361.00 | |||
CapZ-β Antibody (52): m-IgG1 BP-HRP Bundle | sc-543158 | 200 µg Ab; 20 µg BP | $361.00 | |||
CapZ-β Antibody (52) AC | sc-136502 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CapZ-β Antibody (52) HRP | sc-136502 HRP | 200 µg/ml | $322.00 |