CapZ-α1 Antibody (2): sc-130309
- CapZ-α1 Antibody (2) is a mouse monoclonal IgG1 κ CapZ-α1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against recombinant CapZ-α1 of human origin
- CapZ- alpha 1 Antibody (2) is recommended for detection of CapZ-α1 of mouse, rat and human origin by WB, IP and ELISA
- Anti-CapZ- alpha 1 Antibody (2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CapZ-α1 Antibody (2) for WB applications. These reagents are now offered in bundles with CapZ-α1 Antibody (2) (see ordering information below).
CapZ-α1 Antibody (2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CapZ-α1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CapZ-α1 antibody (2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CapZ-α1, also known as F-Actin-capping protein subunit alpha-1, plays a crucial role in regulating actin dynamics by binding to barbed ends of actin filaments, thereby preventing further polymerization and stabilizing filament structure. This function is vital for maintaining cellular architecture and facilitating processes such as cell motility, division, and intracellular transport. Additionally, CapZ-α1 interacts with S-100 β chain, a calcium-binding protein implicated in intermediate filament assembly and associated with neurodegenerative conditions like Alzheimer′s disease. CapZ-α1′s ability to modulate actin filament growth and involvement in signaling pathways underscores CapZ-α1′s importance in both normal cellular function and disease states, making CapZ-α1 (2) monoclonal antibody an essential tool for researchers studying cytoskeletal dynamics and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CapZ-α1 Antibody (2) References:
- Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12. | Inman, KG., et al. 2002. J Mol Biol. 324: 1003-14. PMID: 12470955
- Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. | Hutchings, NJ., et al. 2003. J Biol Chem. 278: 22396-403. PMID: 12690097
- Arabidopsis capping protein (AtCP) is a heterodimer that regulates assembly at the barbed ends of actin filaments. | Huang, S., et al. 2003. J Biol Chem. 278: 44832-42. PMID: 12947123
- How capping protein binds the barbed end of the actin filament. | Wear, MA., et al. 2003. Curr Biol. 13: 1531-7. PMID: 12956956
- Searching for the missing link: a role for the actin capping protein in heart failure. | Pyle, WG. 2004. Can J Cardiol. 20: 1429-32. PMID: 15614336
- WNT2B: comparative integromics and clinical applications (Review). | Katoh, M. 2005. Int J Mol Med. 16: 1103-8. PMID: 16273293
- New insights into mechanism and regulation of actin capping protein. | Cooper, JA. and Sept, D. 2008. Int Rev Cell Mol Biol. 267: 183-206. PMID: 18544499
- Interaction of Cap Z with actin. The NH2-terminal domains of the alpha 1 and beta subunits are not required for actin capping, and alpha 1 beta and alpha 2 beta heterodimers bind differentially to actin. | Casella, JF. and Torres, MA. 1994. J Biol Chem. 269: 6992-8. PMID: 8120062
- Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. | Hart, MC., et al. 1997. Cell Motil Cytoskeleton. 38: 120-32. PMID: 9331217
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CapZ-α1 Antibody (2) | sc-130309 | 200 µg/ml | $322.00 | |||
CapZ-α1 Antibody (2): m-IgG Fc BP-HRP Bundle | sc-528728 | 200 µg Ab; 10 µg BP | $361.00 | |||
CapZ-α1 Antibody (2): m-IgGκ BP-HRP Bundle | sc-521207 | 200 µg Ab, 40 µg BP | $361.00 | |||
CapZ-α1 Antibody (2): m-IgG1 BP-HRP Bundle | sc-543096 | 200 µg Ab; 20 µg BP | $361.00 | |||
CapZ-α1 Antibody (2) AC | sc-130309 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CapZ-α1 Antibody (2) HRP | sc-130309 HRP | 200 µg/ml | $322.00 | |||
CapZ-α1 Antibody (2) FITC | sc-130309 FITC | 200 µg/ml | $336.00 | |||
CapZ-α1 Antibody (2) PE | sc-130309 PE | 200 µg/ml | $349.00 | |||
CapZ-α1 Antibody (2) Alexa Fluor® 488 | sc-130309 AF488 | 200 µg/ml | $364.00 | |||
CapZ-α1 Antibody (2) Alexa Fluor® 546 | sc-130309 AF546 | 200 µg/ml | $364.00 | |||
CapZ-α1 Antibody (2) Alexa Fluor® 594 | sc-130309 AF594 | 200 µg/ml | $364.00 | |||
CapZ-α1 Antibody (2) Alexa Fluor® 647 | sc-130309 AF647 | 200 µg/ml | $364.00 | |||
CapZ-α1 Antibody (2) Alexa Fluor® 680 | sc-130309 AF680 | 200 µg/ml | $364.00 | |||
CapZ-α1 Antibody (2) Alexa Fluor® 790 | sc-130309 AF790 | 200 µg/ml | $364.00 |