CAPS-1 Antibody (G-12): sc-377279
- CAPS-1 Antibody (G-12) is a mouse monoclonal IgG1 κ CAPS-1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1001-1060 mapping within an internal region of CAPS-1 of human origin
- CAPS-1 Antibody (G-12) is recommended for detection of CAPS-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CAPS-1 Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CAPS-1 Antibody (G-12). This work is in progress.
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CAPS-1 Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects CAPS-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CAPS-1 Antibody (G-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CAPS-1, a calcium-dependent secretion activator, plays a crucial role in the regulation of neurotransmitter and neuropeptide release by facilitating the transport of secretory granules to the cell membrane for exocytosis. CAPS-1 is predominantly expressed in the brain, where CAPS-1 is essential for the proper secretion of various neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). The structure of CAPS-1 includes a pleckstrin homology (PH) domain, which is vital for interaction with phospholipids and regulation of exocytosis. This structural feature allows CAPS-1 to effectively mediate the release of catecholamines from neuronal cells, thereby influencing neuronal signaling and development. Mutations or defects in the genes encoding CAPS-1 and CAPS-2 have been associated with neurodevelopmental disorders, including autism, highlighting the significance of CAPS-1 in both normal brain function and the pathogenesis of neurological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CAPS-1 Antibody (G-12) References:
- Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. | Cisternas, FA., et al. 2003. Genomics. 81: 279-91. PMID: 12659812
- A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. | Speidel, D., et al. 2003. J Biol Chem. 278: 52802-9. PMID: 14530279
- CAPS acts at a prefusion step in dense-core vesicle exocytosis as a PIP2 binding protein. | Grishanin, RN., et al. 2004. Neuron. 43: 551-62. PMID: 15312653
- CAPS1 regulates catecholamine loading of large dense-core vesicles. | Speidel, D., et al. 2005. Neuron. 46: 75-88. PMID: 15820695
- Differential distributions of the Ca2+ -dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain. | Sadakata, T., et al. 2006. J Comp Neurol. 495: 735-53. PMID: 16506193
- Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain. | Sadakata, T. and Furuichi, T. 2006. Neurosci Lett. 405: 217-22. PMID: 16901643
- Tissue distribution of Ca2+-dependent activator protein for secretion family members CAPS1 and CAPS2 in mice. | Sadakata, T., et al. 2007. J Histochem Cytochem. 55: 301-11. PMID: 17164411
- Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. | Sadakata, T., et al. 2007. J Neurosci. 27: 2472-82. PMID: 17344385
- Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. | Sadakata, T., et al. 2007. BMC Neurosci. 8: 25. PMID: 17428348
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAPS-1 Antibody (G-12) | sc-377279 | 200 µg/ml | $316.00 | |||
CAPS-1 Antibody (G-12) AC | sc-377279 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CAPS-1 Antibody (G-12) HRP | sc-377279 HRP | 200 µg/ml | $316.00 | |||
CAPS-1 Antibody (G-12) FITC | sc-377279 FITC | 200 µg/ml | $330.00 | |||
CAPS-1 Antibody (G-12) PE | sc-377279 PE | 200 µg/ml | $343.00 | |||
CAPS-1 Antibody (G-12) Alexa Fluor® 488 | sc-377279 AF488 | 200 µg/ml | $357.00 | |||
CAPS-1 Antibody (G-12) Alexa Fluor® 546 | sc-377279 AF546 | 200 µg/ml | $357.00 | |||
CAPS-1 Antibody (G-12) Alexa Fluor® 594 | sc-377279 AF594 | 200 µg/ml | $357.00 | |||
CAPS-1 Antibody (G-12) Alexa Fluor® 647 | sc-377279 AF647 | 200 µg/ml | $357.00 | |||
CAPS-1 Antibody (G-12) Alexa Fluor® 680 | sc-377279 AF680 | 200 µg/ml | $357.00 | |||
CAPS-1 Antibody (G-12) Alexa Fluor® 790 | sc-377279 AF790 | 200 µg/ml | $357.00 |