CaMKII gamma Antibody (8G10C1): sc-517238

CaMKIIγ Antibody (8G10C1) is a mouse monoclonal IgG1 antibody specifically engineered to detect CaMKIIγ protein, also known as CAMK2G, across human and rat species. Anti-CaMKIIγ antibody (8G10C1) targets a recombinant epitope corresponding to amino acids 322-481 of human CaMKIIγ, ensuring reliable performance in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). CaMKIIγ is a critical member of the Ca²⁺/calmodulin-dependent protein kinase II family, functioning as a key mediator in calcium signaling pathways that regulate essential cellular processes such as cell cycle and gene transcription. Predominantly located in cytoplasm, CaMKIIγ can translocate to other cellular compartments in response to calcium oscillations, which is vital for interaction with diverse substrates and modulation of cellular functions. Structurally, CaMKIIγ consists of a catalytic domain responsible for kinase activity, a regulatory domain that governs activation upon calcium/calmodulin binding, and an association domain that facilitates assembly of multimeric holoenzymes, essential for regulatory mechanisms. CaMKIIγ (8G10C1) monoclonal antibody serves as an indispensable tool for researchers aiming to elucidate complex roles of this kinase in both normal physiology and disease states.

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CaMKII gamma Antibody (8G10C1) References:

1. Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis.  |  Gu, Y., et al. 2016. Leukemia. 30: 1282-9. PMID: 27012864
2. Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.  |  Gu, Y., et al. 2017. Cancer Cell. 32: 115-128.e7. PMID: 28697340
3. CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.  |  Doran, AC., et al. 2017. J Clin Invest. 127: 4075-4089. PMID: 28972541
4. Prostaglandin F2α Facilitates Hepatic Glucose Production Through CaMKIIγ/p38/FOXO1 Signaling Pathway in Fasting and Obesity.  |  Wang, Y., et al. 2018. Diabetes. 67: 1748-1760. PMID: 29773555
5. Novel synthetic tosyl chloride-berbamine regresses lethal MYC-positive leukemia by targeting CaMKIIγ/Myc axis.  |  Yu, Q., et al. 2019. Biomed Pharmacother. 117: 109134. PMID: 31247466
6. CAMKIIγ is a targetable driver of multiple myeloma through CaMKIIγ/ Stat3 axis.  |  Yang, L., et al. 2020. Aging (Albany NY). 12: 13668-13683. PMID: 32658867
7. Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway.  |  Gu, J., et al. 2021. BMC Complement Med Ther. 21: 163. PMID: 34088288
8. Antiangiogenic and antitumor potential of berbamine, a natural CaMKIIγ inhibitor, against glioblastoma.  |  Kim, YJ., et al. 2021. Biochem Biophys Res Commun. 566: 129-134. PMID: 34119825
9. LncRNA GAS5 promotes epilepsy progression through the epigenetic repression of miR-219, in turn affecting CaMKIIγ/NMDAR pathway.  |  Zhao, CS., et al. 2022. J Neurogenet. 36: 32-42. PMID: 35642561
10. The phosphorylation of Smad3 by CaMKIIγ leads to the hepatocyte pyroptosis under perfluorooctane sulfonate exposure.  |  Ren, S., et al. 2024. Ecotoxicol Environ Saf. 284: 116924. PMID: 39181077

The preferred p-CaMKII antibody is p-CaMKII Antibody (22B1): sc-32289.