CaMKII delta Antibody (L-04): sc-100362

CaMKIIδ Antibody (L-04) is a mouse monoclonal IgG2b antibody that detects CaMKII delta in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CaMKII delta antibody (L-04) is available as a non-conjugated format. CaMKII delta plays a crucial role in various cellular processes, particularly in regulating synaptic plasticity and memory formation in the brain. CaMKII delta is predominantly located in the postsynaptic density of neurons, where CaMKII delta is involved in phosphorylating various substrates that modulate synaptic strength and neuronal signaling pathways. Proper functioning of CaMKII delta is essential for long-term potentiation, a cellular mechanism underlying learning and memory. Dysregulation of CaMKII delta has been implicated in several neurological disorders, making CaMKII delta a significant target for research in neurobiology and potential therapeutic interventions. Anti-CaMKII delta antibody (L-04)′s ability to specifically recognize CaMKII delta across different species enhances utility in comparative studies and translational research, providing valuable insights into molecular mechanisms of synaptic function and dysfunction.

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CaMKII delta Antibody (L-04) References:

1. The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct delta-CaM kinase isozyme.  |  Baltas, LG., et al. 1995. FEBS Lett. 373: 71-5. PMID: 7589437
2. Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.  |  Tokumitsu, H., et al. 1995. J Biol Chem. 270: 19320-4. PMID: 7642608
3. Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.  |  Hama, N., et al. 1995. J Exp Med. 181: 1217-22. PMID: 7869038
4. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase).  |  Tombes, RM., et al. 1995. Cell Growth Differ. 6: 1063-70. PMID: 8519682
5. Overexpression of Ca2+/calmodulin-dependent protein kinase II inhibits neurite outgrowth of PC12 cells.  |  Tashima, K., et al. 1996. J Neurochem. 66: 57-64. PMID: 8522989
6. Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T lymphocytes.  |  Park, IK. and Soderling, TR. 1995. J Biol Chem. 270: 30464-9. PMID: 8530476

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CaMKII delta Antibody (L-04) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-CaMKII delta Antibody (L-04) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CaMKII delta Antibody (L-04) Specifications

Alternate Product Name: CAMK2D

Product Clone Name: L-04

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b lambda light chain

Amino Acids: 301-410

Epitope Target: CaMKIIδ

Epitope Species: human

Product Reactivity/Detection: CaMKIIδ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for CaMKII delta Antibody (L-04): N/A

The preferred p-CaMKII antibody is p-CaMKII Antibody (22B1): sc-32289.