CAMK2A/CaMKII alpha Antibody (A-1): sc-13141

CaMKIIα Antibody (A-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects CaMKII alpha in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CaMKIIα (A-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CaMKII alpha plays a crucial role in cellular signaling pathways, particularly in the regulation of synaptic plasticity and memory formation in neurons, making CaMKII alpha essential for cognitive functions. CaMKII alpha is primarily located in the cytoplasm and is also found in the nucleus, where CaMKII alpha can influence gene expression and cellular responses to calcium signaling. CaMKII alpha translocation to the nucleus upon activation highlights CaMKII alpha importance in mediating long-term changes in neuronal function and plasticity. Additionally, CaMKII alpha undergoes various post-translational modifications, including phosphorylation, which can modulate CaMKII alpha activity and interactions with other proteins, further emphasizing CaMKII alpha role in complex signaling networks. CaMKIIα (A-1) monoclonal antibody enables researchers to gain valuable insights into the mechanisms underlying calcium-dependent signaling and implications in neurobiology and other physiological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CAMK2A/CaMKII alpha Antibody (A-1) References:

1. The cardiac sarcoplasmic reticulum phospholamban kinase is a distinct delta-CaM kinase isozyme.  |  Baltas, LG., et al. 1995. FEBS Lett. 373: 71-5. PMID: 7589437
2. Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase.  |  Tokumitsu, H., et al. 1995. J Biol Chem. 270: 19320-4. PMID: 7642608
3. Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells.  |  Hama, N., et al. 1995. J Exp Med. 181: 1217-22. PMID: 7869038
4. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase).  |  Tombes, RM., et al. 1995. Cell Growth Differ. 6: 1063-70. PMID: 8519682
5. Overexpression of Ca2+/calmodulin-dependent protein kinase II inhibits neurite outgrowth of PC12 cells.  |  Tashima, K., et al. 1996. J Neurochem. 66: 57-64. PMID: 8522989
6. Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T lymphocytes.  |  Park, IK. and Soderling, TR. 1995. J Biol Chem. 270: 30464-9. PMID: 8530476

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CAMK2A/CaMKII alpha Antibody (A-1) has 73 citations in a variety of scientific publications.

Primary antibodies like Anti-CAMK2A/CaMKII alpha Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CAMK2A/CaMKII alpha Antibody (A-1) Specifications

Alternate Product Name: CAMK2A

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 303-478

Epitope Target: CaMKIIα

Epitope Species: mouse

Product Reactivity/Detection: CaMKIIα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 73 citations in various scientific publications

Available Conjugates/Forms for CAMK2A/CaMKII alpha Antibody (A-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred p-CaMKII antibody is p-CaMKII Antibody (22B1): sc-32289.