Calregulin Antibody (1G6A7): sc-101436
- Calregulin Antibody (1G6A7) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against a synthetic peptide corresponding to amino acids 405-417 of Calregulin of human origin
- recommended for detection of Calregulin of mouse, rat and human origin by WB, IP and ELISA
- See Calregulin (F-4): sc-373863 for Calregulin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Calregulin Antibody (1G6A7) for WB applications. This reagent is now offered in a bundle with Calregulin Antibody (1G6A7) (see ordering information below).
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Calregulin Antibody (1G6A7) is a mouse monoclonal IgG2a light chain antibody that detects calregulin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Calregulin, also known as calreticulin, is a calcium-binding protein predominantly located in the lumen of the endoplasmic reticulum, where calregulin plays a crucial role in calcium homeostasis and protein folding. Calregulin′s ability to bind calcium with both low- and high-affinity sites is essential for calregulin′s function in the proper maturation of glycoproteins, as calregulin assists in the folding process and prevents the aggregation of misfolded proteins. This is particularly important in maintaining cellular health and function, as improperly folded proteins can lead to cellular stress and contribute to various diseases. Anti-calregulin antibody (1G6A7) provides reliable detection of calregulin, facilitating research into calregulin′s role in cellular processes and implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Calregulin Antibody (1G6A7) References:
- Calreticulin exposure dictates the immunogenicity of cancer cell death. | Obeid, M., et al. 2007. Nat Med. 13: 54-61. PMID: 17187072
- Calreticulin and focal-contact-dependent adhesion. | Villagomez, M., et al. 2009. Biochem Cell Biol. 87: 545-56. PMID: 19767819
- Somatic mutations of calreticulin in myeloproliferative neoplasms. | Klampfl, T., et al. 2013. N Engl J Med. 369: 2379-90. PMID: 24325356
- Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER/SR protein. | Smith, MJ. and Koch, GL. 1989. EMBO J. 8: 3581-6. PMID: 2583110
- Anti-calreticulin antibodies and calreticulin in sera of patients diagnosed with dilated or hypertrophic cardiomyopathy. | Sánchez, D., et al. 2016. Autoimmunity. 49: 554-562. PMID: 27689957
- Secreted calreticulin mutants subvert anticancer immunosurveillance. | Liu, P., et al. 2020. Oncoimmunology. 9: 1708126. PMID: 32002304
- Mutant Calreticulin in the Myeloproliferative Neoplasms. | Prins, D., et al. 2020. Hemasphere. 4: e333. PMID: 32382708
- Calreticulin Exposure in Mitotic Catastrophe. | Bezu, L., et al. 2021. Methods Mol Biol. 2267: 207-215. PMID: 33786794
- Calreticulin exposure orchestrates innate immunosurveillance. | Guilbaud, E., et al. 2023. Cancer Cell. 41: 1014-1016. PMID: 37207656
- Antibody targeting of mutant calreticulin in myeloproliferative neoplasms. | Kramer, F. and Mullally, A. 2024. J Cell Mol Med. 28: e17896. PMID: 37551061
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calregulin Antibody (1G6A7) | sc-101436 | 200 µg/ml | $322.00 | |||
Calregulin Antibody (1G6A7): m-IgG Fc BP-HRP Bundle | sc-539765 | 200 µg Ab; 10 µg BP | $361.00 |