Calpastatin Antibody (2Q31): sc-70486
- Calpastatin Antibody (2Q31) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against human erythrocyte calpastatin
- recommended for detection of Calpastatin of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Calpastatin Antibody (2Q31) for WB applications. These reagents are now offered in bundles with Calpastatin Antibody (2Q31) (see ordering information below).
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Calpastatin Antibody (2Q31) is a mouse monoclonal IgG1 antibody that detects Calpastatin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Calpastatin plays a crucial role in regulating calpain activity, which is essential for various cellular processes, including cell signaling, differentiation, and apoptosis. By inhibiting calpain, Calpastatin ensures that proteolytic activity is tightly controlled, preventing unwanted degradation of vital cellular proteins. This regulation is particularly important in tissues where calpain activity must be precisely modulated, such as during spermatogenesis and in response to cellular stress. The interaction between Calpastatin and calpain is vital for maintaining cellular homeostasis, and dysregulation of this balance can lead to pathological conditions, including neurodegenerative diseases and cancer. Anti-Calpastatin antibody (2Q31) is an invaluable tool for researchers studying these processes, providing insights into the intricate mechanisms of protease regulation and its implications in health and disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Calpastatin Antibody (2Q31) References:
- Calpastatin is regulated by protein never in mitosis gene A interacting-1 (PIN1) in endothelial cells. | Liu, T., et al. 2011. Biochem Biophys Res Commun. 414: 581-6. PMID: 21982763
- Differential regulation of the calpain-calpastatin complex by the L-domain of calpastatin. | De Tullio, R., et al. 2014. Biochim Biophys Acta. 1843: 2583-91. PMID: 25026177
- Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice. | Rao, MV., et al. 2016. J Neurochem. 137: 253-65. PMID: 26756888
- Calpastatin ablation aggravates the molecular phenotype in cell and animal models of Huntington disease. | Weber, JJ., et al. 2018. Neuropharmacology. 133: 94-106. PMID: 29355642
- Calpastatin participates in the regulation of cell migration in BAP1-deficient uveal melanoma cells. | Yue, H., et al. 2019. Int J Ophthalmol. 12: 1680-1687. PMID: 31741854
- Skeletal muscle-specific calpastatin overexpression mitigates muscle weakness in aging and extends life span. | Schroder, EA., et al. 2021. J Appl Physiol (1985). 131: 630-642. PMID: 34197232
- Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease. | Hu, D., et al. 2021. Nat Commun. 12: 5305. PMID: 34489447
- The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome. | McGonigal, R., et al. 2023. J Peripher Nerv Syst. 28: 4-16. PMID: 36335586
- Formation of the calpain-1/calpastatin complex promotes activation of calpain-1 under oxidizing conditions. | Maddock Carlin, KR., et al. 2024. J Anim Sci. 102: PMID: 38738874
- The calpain-calpastatin system in rheumatoid arthritis. | Ménard, HA. and el-Amine, M. 1996. Immunol Today. 17: 545-7. PMID: 8991283
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Calpastatin Antibody (2Q31) | sc-70486 | 200 µg/ml | $316.00 | |||
Calpastatin Antibody (2Q31): m-IgG Fc BP-HRP Bundle | sc-537193 | 200 µg Ab; 10 µg BP | $354.00 | |||
Calpastatin Antibody (2Q31): m-IgGκ BP-HRP Bundle | sc-534397 | 200 µg Ab; 40 µg BP | $354.00 | |||
Calpastatin Antibody (2Q31): m-IgG1 BP-HRP Bundle | sc-545069 | 200 µg Ab; 20 µg BP | $354.00 |